Kawakami et al., Circulation 2006
(Atherosclerosis...) :
PKCbeta inhibition abolished apoCIII induced NF-kappaB activation, and NF-kappaB inhibition reduced expression of VCAM-1, each resulting in reduced THP-1 cell adhesion
Kawakami et al., Arterioscler Thromb Vasc Biol 2007
:
ApoCIII further activated nuclear factor-kappaB (NF-kappaB) through PKC alpha in THP-1 cells and augmented beta1-integrin expression
Gruber et al., Nucleic Acids Res 1994
:
These results indicate that apo CIII gene expression is regulated by NF-kappa B , and suggest that apo CIII production may be modulated by cellular signals, like inflammatory cytokines, that activate NF-kB