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MYLIP — PCNA
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Lee et al., Biochem Biophys Res Commun 2008
:
Here, we show that
miR-302b indirectly regulates expression of the pluripotent stem cell marker Oct4, and it directly
regulates expression of
Cyclin D2 protein, a developmental regulator during gastrulation
Xu et al., J Biol Chem 2010
:
We found that overexpression of
miR-223 , in particular, significantly reduces FBXW7 mRNA levels,
increases endogenous
cyclin E protein and activity levels, and increases genomic instability
Lu et al., Cancer Res 2011
(Nasopharyngeal Neoplasms) :
Interestingly,
cyclin D2 was
regulated by
miR-26a but not by EZH2, revealing cyclin D2 as another direct yet mechanistically distinct target of miR-26a
Hennessy et al., J Biol Chem 2011
:
We have found that the putative miR-107 target
cyclin dependent kinase 6 (CDK6) expression is increased by TLR4 as a
result of the decrease in
miR-107
Zhang et al., Leukemia & lymphoma 2012
(Lymphoma) :
Overexpression of
miR-297b-5p/3p also
led to altered expression of p27 ( Kip1 ) and
proliferating cell nuclear antigen , abnormal cell cycle arrest, decreased cell proliferation, migration and invasion in vitro in cell cultures, and suppressed xenograft tumor growth in vivo in the nude mouse
Zhang et al., PloS one 2012
(MAP Kinase Signaling System) :
Additionally, we show that both
miR-1 and miR-133
reduce Cyclin D1 expression and repress myoblast proliferation by inducing G1 phase arrest
Pan et al., Int J Immunopathol Pharmacol 2012
(Brain Neoplasms...) :
As a consequence,
miR-149 inhibited the expression of p-AKT1,
PCNA , CyclinD1 and MMP-2, reduced the proliferative activities and invasive potential, and induced cycle arrest in G0/G1 phase in U251 cells
Khan et al., PloS one 2013
:
The
effect of
miR-379 on
Cyclin B1 protein expression and function was investigated using western blot, immunohistochemistry and proliferation assays respectively