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PDGFB — TAGLN

Text-mined interactions from Literome

Lu et al., Dev Biol 2001 : We report here that PDGF-BB stimulates EMT and promotes SRF dependent expression of SMC marker genes calponin, SM22alpha , and SMgamma ( actin ) ( SMgammaA ) in proepicardial cells
Kaplan-Albuquerque et al., Am J Physiol Heart Circ Physiol 2003 : Regulation of SM22 alpha expression by arginine vasopressin and PDGF-BB in vascular smooth muscle cells
Wamhoff et al., Circ Res 2004 (Arteriosclerosis...) : Consistent with this hypothesis, results of studies in cultured SMCs showed that : ( 1 ) PDGF-BB increased expression of Sp1 ; ( 2 ) PDGF-BB and Sp1 profoundly suppressed SM22alpha promoter activity as well as smooth muscle myosin heavy chain promoter activity through mechanisms that were at least partially dependent on the G/C cis element ; and ( 3 ) a short interfering RNA to Sp1 increased basal expression and attenuated PDGF-BB induced suppression of SM22alpha
Chen et al., J Biol Chem 2009 : Knockdown of FRS2 in VSMC by RNA interference inhibited PDGF-BB mediated down-regulation of SMA and SM22alpha without affecting PDGF-BB mediated cell proliferation or ERK activation