Gene interactions and pathways from curated databases and text-mining

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IL8 — TNFRSF1A

Text-mined interactions from Literome

Todd et al., Immunology 2004 (Familial Mediterranean Fever) : Furthermore, as expected, WT and mutant deltasig forms of TNFRSF1A did not induce apoptosis or interleukin-8 production
Su et al., Exp Cell Res 2006 (MAP Kinase Signaling System) : Although both DR3 and TNFRI activated TRAF2 and NF-kappaB to induce IL-8 gene transcription, the kinase cascades that transduce signals for DR3- and TNFRI induced IL-8 gene transcription are different ... The axis TAK1/ASK1-MKK4/MKK7-JNK2 is responsible for DR3 mediated IL-8 gene expression whereas the axis ASK1-MKK4-JNK1/JNK2/p38MAPK is the choice for TNFRI mediated activation of IL-8 gene expression
Ogilvie et al., Int J Immunopathol Pharmacol 2006 (Psoriasis) : mRNA expression of IL-8 and IL-20 completely disappeared and mRNA expression of TNF-R p60 was reduced after therapy
Kunisch et al., Ann Rheum Dis 2007 (Arthritis, Rheumatoid...) : Reduction of proliferation and induction of IL6, IL8 and MMP-1 were solely mediated by TNF-R1 , whereas PGE ( 2 ) and MMP-3 secretion was mediated by both TNF-Rs
Dudez et al., Biochim Biophys Acta 2008 : Activation of TNFR1 signaling also decreased GJIC and markedly stimulated IL-8 production in WtCFTR cells
Moh et al., FASEB J 2013 : Activation of TNFR1 by TNF protein additively augments CD137L induced IL-8 expression ... Conversely, inhibition of TNFR1 activity by a TNFR1 neutralizing antibody inhibits CD137L mediated cell adhesion, cell death, CD14 expression, and IL-8 production
Butler et al., Eur Cytokine Netw 1994 (Arthritis, Rheumatoid) : Both p55 and p75 TNF receptors on dermal and gingival fibroblasts were also involved in TNF-alpha mediated DNA synthesis and IL-6, IL-8 and PGE2 release, although differences in the levels of DNA synthesis and release of inflammatory cytokines and PGE2 were observed between the three fibroblast types