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IL8 — TNFRSF1A
Text-mined interactions from Literome
Todd et al., Immunology 2004
(Familial Mediterranean Fever) :
Furthermore, as expected, WT and mutant deltasig forms of
TNFRSF1A did not
induce apoptosis or
interleukin-8 production
Su et al., Exp Cell Res 2006
(MAP Kinase Signaling System) :
Although both DR3 and TNFRI activated TRAF2 and NF-kappaB to induce IL-8 gene transcription, the kinase cascades that transduce signals for DR3- and
TNFRI induced
IL-8 gene transcription are different ... The axis TAK1/ASK1-MKK4/MKK7-JNK2 is responsible for DR3 mediated IL-8 gene expression whereas the axis ASK1-MKK4-JNK1/JNK2/p38MAPK is the choice for
TNFRI mediated activation of
IL-8 gene expression
Ogilvie et al., Int J Immunopathol Pharmacol 2006
(Psoriasis) :
mRNA expression of
IL-8 and IL-20 completely disappeared and mRNA expression of TNF-R
p60 was
reduced after therapy
Kunisch et al., Ann Rheum Dis 2007
(Arthritis, Rheumatoid...) :
Reduction of proliferation and induction of IL6,
IL8 and MMP-1 were solely
mediated by
TNF-R1 , whereas PGE ( 2 ) and MMP-3 secretion was mediated by both TNF-Rs
Dudez et al., Biochim Biophys Acta 2008
:
Activation of
TNFR1 signaling also decreased GJIC and markedly
stimulated IL-8 production in WtCFTR cells
Moh et al., FASEB J 2013
:
Activation of
TNFR1 by TNF protein additively
augments CD137L induced
IL-8 expression ... Conversely, inhibition of
TNFR1 activity by a TNFR1 neutralizing antibody
inhibits CD137L mediated cell adhesion, cell death, CD14 expression, and
IL-8 production
Butler et al., Eur Cytokine Netw 1994
(Arthritis, Rheumatoid) :
Both
p55 and p75 TNF receptors on dermal and gingival fibroblasts were also
involved in TNF-alpha mediated DNA synthesis and IL-6,
IL-8 and PGE2 release, although differences in the levels of DNA synthesis and release of inflammatory cytokines and PGE2 were observed between the three fibroblast types