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CEBPA — PPARG

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CEBPA → PPARG (decreases, PPARG Activity, CEBPA Activity)
  Evidence: The leptin gene is regulated by CEBPA andit was found that PPARG activation by TZDs antagonizes the CEBPA mediated transactivation of the leptin promoter
• FastForward regulation: CEBPA → PPARG (transcriptional regulation, unknown) Yang et al., J Biol Chem 2003*
  Evidence: DNABINDING, REG, PROMACTIVITY
• FastForward regulation: CEBPA → PPARG (transcriptional regulation, increase) Park et al., FEBS Lett 2009*
  Evidence: DNABINDING, REG, PROMACTIVITY
• FastForward regulation: CEBPA → PPARG (transcriptional regulation, increase) Holst et al., Exp Cell Res 2003
  Evidence: DNABINDING, REG, PROMACTIVITY
• WikiPathways Transcription factor regulation in adipogenesis: CEBPA → PPARG (activation)
• WikiPathways Transcription factor regulation in adipogenesis: PPARG → CEBPA (activation)

Text-mined interactions from Literome

Hamm et al., Ann N Y Acad Sci 1999 : Furthermore, ectopic expression of C/EBP alpha in NIH-3T3 cells induces PPAR gamma expression and adipogenesis, but also restores insulin-sensitive glucose transport
Elberg et al., J Biol Chem 2000 : We demonstrate here that C/EBPalpha and C/EBPdelta, but not C/EBPbeta, induce the activity of the PPARgamma2 promoter in transiently transfected 3T3-L1 preadipocytes and bind to two juxtaposed low affinity C/EBP binding sites
Davis et al., J Biol Chem 2004 : In contrast, FoxC2 inhibits the expression of C/EBPalpha , perilipin, and adiponectin even in the presence of potent PPARgamma ligands
Farmer et al., Int J Obes Relat Metab Disord 2005 (MAP Kinase Signaling System...) : Interestingly, expression of the mutant beta-catenin blocks expression of adiponectin and C/EBPalpha in response to the activation of PPARgamma
Zuo et al., J Biol Chem 2006 : To further establish a role for PPARgamma in regulating C/EBP alpha expression, we expressed C/EBP beta in PPARgamma-deficient mouse embryo fibroblasts ( MEFs )
Kim et al., J Bone Miner Res 2007 : Furthermore, 20S and Shh greatly inhibited PPARgamma2 promoter activity induced by CCAAT/enhancer binding protein alpha overexpression
Choi et al., Life Sci 2009 : In the early stage of adipogenesis, magnolol induced gene expression of C/EBPdelta, C/EBPalpha and PPARgamma2 and during adipocyte differentiation, it also induced the expression of PPARgamma target genes such as aP2, LPL and adiponectin
Cho et al., Cell Metab 2009 : PTIP deletion in MEFs leads to marked decreases of PPARgamma expression and PPARgamma stimulated C/EBPalpha expression
Schwarz et al., Mol Cell Biol 1997 : Here we report that ectopic expression of either C/EBPalpha or C/EBPbeta induces PPARgamma expression and adipogenesis and that retinoic acid ( RA ) completely inhibits adipogenesis by either form of C/EBP