UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to STAT1

STAT1 — TRADD

Pathways - manually collected, often from reviews:

NCI Pathway Database TNF receptor signaling pathway : FADD (FADD) → sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF) (modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/TRAF2 complex (TNFRSF1A-TRADD-TRAF2-TNF) → sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF) (modification, collaborate)
Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Hsu et al., Cell 1996
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF) → sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF) (modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF) → STAT1 (STAT1) (modification, collaborate) Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF) → sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF) (modification, collaborate)
Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD complex (TNFRSF1A-TRADD-TNF) → STAT1 (STAT1) (modification, collaborate) Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF) → STAT1 (STAT1) (modification, collaborate) Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF) → RIP (RIPK1) (modification, collaborate) Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction
NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/STAT1 (dimer) complex (TNFRSF1A-TRADD-STAT1-TNF) → TRAF2 (TRAF2) (modification, collaborate) Wang et al., Mol Cell Biol 2000, Trompouki et al., Nature 2003, Brummelkamp et al., Nature 2003, Kovalenko et al., Nature 2003, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006, Hsu et al., Cell 1996, Hsu et al., Immunity 1996, Jiang et al., Science 1999
Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: STAT1 — TRADD (physical association, affinity chromatography technology) Wang et al., Mol Cell Biol 2000
IRef Biogrid Interaction: STAT1 — TRADD (direct interaction, pull down) Wang et al., Mol Cell Biol 2000
IRef Hprd Interaction: TRADD — STAT1 (in vitro) Wang et al., Mol Cell Biol 2000
IRef Hprd Interaction: TRADD — STAT1 (in vivo) Wang et al., Mol Cell Biol 2000
IRef Ophid Interaction: STAT1 — TRADD (aggregation, confirmational text mining) Wang et al., Mol Cell Biol 2000
IRef Ophid Interaction: STAT1 — TRADD (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Wang et al., Mol Cell Biol 2000 : Here we show that Stat1 is involved in the TNFR1-TRADD signaling complex, as determined by employing a novel antibody array screening method
Wesemann et al., Nat Immunol 2004 : These data indicate that TRADD may be involved in IFN-gamma signaling by forming a complex with STAT1-alpha within the nucleus and regulating IFN-gamma mediated STAT1-alpha activation