Gene interactions and pathways from curated databases and text-mining

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HBEGF — JUN

Text-mined interactions from Literome

Fu et al., Proc Natl Acad Sci U S A 1999 (Cell Transformation, Neoplastic) : In this system, induction of v-Jun is followed within 1 hr by elevated levels of HB-EGF
Park et al., Am J Physiol 1999 : AP-1 mediates stretch induced expression of HB-EGF in bladder smooth muscle cells
Koh et al., J Biochem 2001 : Electrophoretic mobility shift assay also showed the involvement of AP-1 in HB-EGF gene expression by glucose
Zenz et al., Dev Cell 2003 (Genetic Predisposition to Disease...) : Thus, using three experimental systems, we show that EGFR and HB-EGF are regulated by c-Jun , which controls eyelid development, keratinocyte proliferation, and skin tumor formation
Wang et al., Oncogene 2007 (Neoplasms) : Using RNA interference, we demonstrated that the chemotherapy induced HB-EGF was largely dependent on activator protein-1 (AP-1) and NF-kappaB activation