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JUN — TIMP1
Text-mined interactions from Literome
Bahr et al., Hepatology 1999
:
Previous work in other cell lineages has established a key role for Pea3 binding proteins ( Ets-1 ) in
AP-1 mediated transactivation of the
TIMP-1 promoter ... Mutations of the AP-1 site of the TIMP-1 promoter that prevented formation of HMAP-1 caused a 70 % loss of activity in transfected activated HSCs. Taken together the data indicate that sustained upregulation of TIMP-1 gene expression may be at least partially controlled by a novel
AP-1 dependent
regulation of
TIMP-1 promoter activity
Sato et al., Cancer Res 2002
(Fibrosarcoma...) :
Inhibition of
activator protein-1 binding activity and phosphatidylinositol 3-kinase pathway by nobiletin, a polymethoxy flavonoid,
results in augmentation of
tissue inhibitor of metalloproteinases-1 production and suppression of production of matrix metalloproteinases-1 and -9 in human fibrosarcoma HT-1080 cells
Edwards et al., Biochim Biophys Acta 1992
:
Involvement of
AP1 and PEA3 binding sites in the regulation of murine
tissue inhibitor of metalloproteinases-1 ( TIMP-1 ) transcription ... Our data show that binding sites for
AP1 and PEA3 transcription factors are
involved in the regulation of
TIMP-1 transcription, which suggests that the coordinated induction of TIMP-1, collagenase and stromelysin may be achieved through the actions of a shared set of nuclear transcription factors
Kwak et al., Mol Cancer Res 2006
(Fibrosarcoma...) :
Mithramycin, a specific inhibitor of Sp1 transcription factor, but not curcumin, an inhibitor of
activator protein-1 , and transfection of Sp1 small interfering RNA significantly
inhibited the TGF-beta1 induced expression of
TIMP-1
Guo et al., Calcif Tissue Int 2006
:
TIMP-1 activated phosphatidylinositol 3-kinase ( PI3-kinase ) and
c-Jun N-terminal kinase (JNK) , and the PI3-kinase inhibitor LY294002 or the JNK inhibitor SP600125 abolished its antiapoptotic activity
Wang et al., Apoptosis 2013
(Liver Cirrhosis) :
TIMP1 was transcriptionally
regulated by nuclear factor
c-Jun as demonstrated by EMSA and ChIP assay