Kim et al., Apoptosis 2009
(Neuroblastoma) :
In the presence of high glucose, IRS-1 underwent caspase mediated degradation, followed by focal adhesion kinase ( FAK ) and Akt degradation and apoptosis
Garcia-Diaz et al., J Mol Endocrinol 2010
(Obesity) :
In addition, VC ( 200 microM ) induced Cdkn1a and Casp8 , partially inhibited Irs3 , and together with insulin drastically reduced Gpdh ( listed as Gpd1 in the MGI database ) gene expressions