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FOXO4 — MST1
Text-mined interactions from Literome
Lehtinen et al., Cell 2006
:
MST1 phosphorylates FOXO proteins at a conserved site within the forkhead domain that disrupts their interaction with 14-3-3 proteins,
promotes FOXO nuclear translocation, and thereby induces cell death in neurons
Anand et al., Biochemistry 2008
:
We also identify autophosphorylation sites within the MST1 regulatory region and show that both regulatory region phosphorylation and
MST1 dimerization
contribute to
FoxO phosphorylation
Bi et al., J Biol Chem 2010
:
We also find the S82A ( serine mutated to alanine ) diminishes
MST1 activation and its
effect on the
FOXO transcription activity