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AGTR2 — NFKB1
Text-mined interactions from Literome
Ruiz-Ortega et al., Circ Res 2000
:
AT(1) ( DUP753 ) and
AT(2) ( PD123319 and CGP42112 ) receptor antagonists
inhibited Ang II-induced
NF-kappaB DNA binding in a dose dependent manner ( approximately 85 % for each one ; 10 ( - ) ( 5 ) mol/L at 1 hour )
Lorenzo et al., J Am Soc Nephrol 2002
:
These data demonstrate that, in mesangial cells,
NF-kappaB activation is
mediated by AT(1) and
AT(2) receptors, suggesting a novel intracellular signaling mechanism for AT(2) receptors in the kidney
Wolf et al., Kidney Int 2002
:
Our results clearly demonstrate in various cell lines that Ang II
induces NF-kappaB activation through
AT2 receptors
Wu et al., Mol Endocrinol 2004
:
Ang II stimulation
induced MCP-1 mRNA expression as well as an increase in
nuclear factor-kappaB (NF-kappaB) binding to the corresponding cis DNA element of the MCP-1 promoter region and a decrease in the cytosolic inhibitory protein-kappaB ( IkappaB ) protein level via AT(1) receptor stimulation, whereas stimulation of the
AT(2) receptor decreased Ang II-induced MCP-1 expression, NF-kappaB DNA binding, and IkappaB degradation, suggesting that activation of the AT(2) receptor attenuated AT(1) receptor mediated MCP-1 expression via a decrease in NF-kappaB DNA binding and an increase in IkappaB stability ... Moreover, we demonstrated that
AT(2) receptor stimulation
attenuated TNFalpha mediated
NF-kappaB activation and MCP-1 expression
Wang et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2005
(Disease Models, Animal...) :
NF-KappaB binding activity was
inhibited at 2 and 5 hours of moderate hypothermia in lung tissue ( P < 0.01 ), but there was no difference in pancreatic tissue between normothermic and hypothermic rats at each time point
Hochart et al., Br J Haematol 2006
(Bacterial Infections...) :
Proinflammatory cytokines tumour necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6 and IL-1beta release were subsequently measured by enzyme linked immunosorbent assay at 6 h, and nuclear translocation of the proinflammatory NF-kappaB was assessed
at 2 h. Treatment with pharmacological doses of LMWH and UFH significantly
attenuated LPS induced production of TNF-alpha, IL-8, IL-6 and IL-1beta as well as
NF-kappaB translocation
Klahr et al., Kidney Int Suppl 1997
(Kidney Diseases...) :
ACE inhibition, AT-1 and
AT-2 receptor blockade each differentially
attenuated NF-kappa B isotype activation