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GPI — PTGS1

Text-mined interactions from Literome

Sato et al., J Pharmacol Toxicol Methods 1999 : These results suggest that the elevation of intracellular Ca2+ and the expression of cPLA2, PGHS-1 , and PGHS-2 mRNA cause PGI2 generation
Smith et al., Arterioscler Thromb Vasc Biol 2002 : However, selective inhibition of COX-2, but not COX-1 , blocked PGI2 production under low cholesterol conditions
Harada et al., Am J Physiol Gastrointest Liver Physiol 2003 : These observations strongly suggest that capsaicin-sensitive sensory neurons might release CGRP, thereby increasing the gastric tissue levels of PGI2 and PGE2 by activating COX-1 through activation of the constitutive form of NOS in rats subjected to WIR
Bucher et al., Eur J Pharmacol 2006 (Flushing...) : Our data indicate that PGI2 release following mesenteric traction is mediated by cyclooxygenase-1
Harada et al., J Neurotrauma 2006 (Spinal Cord Injuries) : These observations strongly suggested that compression trauma induced increase in PGI ( 2 ) production in spinal cord tissue might be mainly mediated by COX-1 and PGI ( 2 ) might play a critical role in reduction of motor disturbances following SCI by inhibiting neutrophil accumulation through inhibition of TNF production
Eichstaedt et al., J Surg Res 2010 (Hypercholesterolemia) : We have examined whether gene transfer mediated overexpression of COX-1 in grafted veins ( 1 ) increases PGI ( 2 ) and cyclic AMP ( cAMP ) production, ( 2 ) leads to vasodilation and improved local blood flow in the presence of hypercholesterolemia, and ( 3 ) reduces neointima formation
Liu et al., Exp Physiol 2012 : These results demonstrate an explicit role for endothelial COX-1 in PGI ( 2 ) synthesis and suggest that in given mouse arteries, PGI ( 2 ) mediates not dilatation but rather vasoconstrictor activity, possibly due to a low expression or functional presence of IP receptors, which enables PGI ( 2 ) to act mainly on TP receptors
Liu et al., Exp Physiol 2012 : These results demonstrate an explicit vasodilator role for COX-1 mediated endothelial PGI ( 2 ) synthesis and suggest that the functionally opposing IP and TP receptors concomitantly mediate the vasomotor reaction to PGI ( 2 ), with the dilator activity of IP receptors being compromised by the vasoconstrictor effect of TP receptors and vice versa
Liu et al., Eur J Pharmacol 2013 : These results demonstrate explicitly that in mouse arteries celecoxib not only inhibits COX-1 mediated synthesis of PGI ( 2 ) and probably some other prostanoids, but also causes a reduction in vessel contractility that is independent of either COX-2 or COX-1, leading to an inhibition of COX-1 mediated endothelium dependent contraction with an IC ( 50 ) value far below that of it considered for COX-1
Toniolo et al., PloS one 2013 : In the presence of exogenous arachidonic acid and EGCG, PGI ( 2 ) production was preferentially inhibited by a selective COX-1 inhibitor
Sakata et al., Thromb Res 2013 (Carotid Artery Thrombosis...) : Aspirin inhibits both the cyclooxygenase (COX)-1 dependent production of thromboxane A2 ( TXA2 ) in platelets and COX-2 dependent production of anti-aggregatory prostaglandin I2 (PGI2) in vessel walls, resulting in `` aspirin dilemma. ''
Wu et al., Agents Actions Suppl 1997 (Thrombosis) : Adenovirus mediated COX-1 gene transfer to angioplasty damaged carotid arteries in pigs augmented PGI2 synthesis and prevents thrombus formation
Harada et al., J Lab Clin Med 1997 (Leukopenia) : The increase in WIR induced gastric PGI2 synthesis, mainly mediated by cyclooxygenase-1 , appears important in preventing lesion formation, not only by maintaining gastric mucosal blood flow but also by inhibiting leukocyte activation