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CNN2 — TGFB1
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Sugenoya et al., J Am Soc Nephrol 2002
(Anti-Glomerular Basement Membrane Disease) :
Among the growth factors involved in the mesangial cell pathophysiology, including platelet derived growth factor-BB ( PDGF-BB ), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta1 ( TGF-beta1 ), TNF-alpha potently downregulates basic calponin expression in both the mRNA and protein levels, whereas
TGF-beta1 upregulates the
calponin expression
Compton et al., Dev Dyn 2006
:
In epicardial explants,
TGFbeta1 and TGFbeta2 induce loss of epithelial morphology, cytokeratin, and membrane associated Zonula Occludens-1 and
increase the smooth muscle markers
calponin and caldesmon
Ueki et al., Biochim Biophys Acta 1998
:
Induction of
calponin-h1 by
transforming growth factor-beta1 in cultured human ito cells, LI90