◀ Back to TGFB1

COL1A2 — TGFB1

Text-mined interactions from Literome

Runyan et al., American journal of physiology. Renal physiology 2003 : We previously showed that Smad3 promotes COL1A2 gene activation by TGF-beta1 in human mesangial cells ... Inhibition of PKCdelta by rottlerin decreased basal and TGF-beta1 stimulated collagen I production, mRNA expression, and COL1A2 promoter activity, whereas blockade of conventional PKCs by Gö 6976 had little or no effect
Wendling et al., Mol Pharmacol 2003 : 5-fluorouracil blocks transforming growth factor-beta induced alpha 2 type I collagen gene ( COL1A2 ) expression in human fibroblasts via c-Jun NH2-terminal kinase/activator protein-1 activation
Williams et al., Tissue Eng 2003 : Type I collagen gene expression decreased from 3 to 6 weeks in the presence of TGF-beta1
Kanamaru et al., Nephron. Experimental nephrology 2003 : The functional role of p300 in TGF-beta1/Smad-pathway mediated COL1A2 transcription was investigated in cotransfection experiments using a COL1A2 promoter-luciferase reporter gene construct and p300 expression plasmids ... TGF-beta1 induced COL1A2 gene expression in cultured mouse mesangial cells which was blocked by overexpression of inhibitory Smad7 ... TGF-beta1 induced interaction of endogenous p300 with Smad2/3, and a dominant negative construct of p300 inhibited the TGF-beta1 induced COL1A2 expression in cultured mouse mesangial cells
Runyan et al., J Biol Chem 2004 : We previously showed that Smad3 promotes COL1A2 gene activation by TGF-beta1 in human glomerular mesangial cells ... Similarly, LY294002 or an Akt dominant negative construct blocks TGF-beta1 induction of COL1A2 promoter activity
Ortega-Velazquez et al., Am J Physiol Cell Physiol 2004 : Collagen I upregulates extracellular matrix gene expression and secretion of TGF-beta 1 by cultured human mesangial cells
Asano et al., J Immunol 2004 (Scleroderma, Diffuse) : The TGF-beta1 induced COL1A2 promoter activity, but not the basal activity, was significantly attenuated by LY294002 or the dominant negative mutant of p85 subunit of PI3K, while the constitutive active mutant of p110 subunit of PI3K did not affect the basal or the TGF-beta1 induced COL1A2 promoter activity
Nieto et al., J Biol Chem 2005 (Fibrosis) : S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter
Izumi et al., Am J Physiol Lung Cell Mol Physiol 2006 : COL1A2 promoter activity was dose dependently induced by TGF-beta1 , which was further augmented by adenoviral overexpression of Smad3, but was downregulated by Smad7 ... Under the identical condition, adenoviral overexpression of BMP-7 attenuated the TGF-beta1 dependent COL1A2 promoter activity
Li et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2007 : Collagen I and HSP47 expression could be induced by both 1 ng/mL and 10 ng/mL TGF-beta(1) and collagen I was expressed the most after the treatment with 10 ng/mL TGF-beta(1)
Asano et al., J Biol Chem 2007 : Furthermore, PCAF overexpression reversed the inhibitory effect of Fli1 on TGF-beta1 mediated COL1A2 promoter activity ... In contrast, the Fli1 K380R mutant had a greater inhibitory effect on TGF-beta1 induced COL1A2 promoter activity than wild-type Fli1, and PCAF failed to reverse this effect
Yang et al., Comparative hepatology 2007 : Furthermore, induction of TGF-beta1 increased the alpha-smooth muscle actin ( alpha-SMA ), p-Smad2/3, hydroxyproline and collagen 1A2 (Col 1A2) levels in the liver, suggesting a significant liver fibrosis
Hu et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2007 : TGF-beta1 could induce the transcription and secretion of Type I collagen in HLF-02 cells ( P < 0.05 ) ... AP-1 is responsible for the secrection of TGF-beta1 induced Type I collagen in human lung fibroblasts
Yang et al., Biochem Biophys Res Commun 2008 (Liver Cirrhosis) : Transforming growth factor-beta1 ( TGF-beta1 ) mediates expression of collagen 1A2 (Col 1A2) gene via a synergistic cooperation between Smad2/Smad3 and Sp1, both act on the Col 1A2 gene promoter ... These results suggest that PL inhibits TGF-beta1 induced Col 1A2 promoter activity through blocking ROS and calcium influx as well as impeding Sp1 binding and translocalization of pSmad 2/3-Smad4 complex into nucleus
Hubchak et al., American journal of physiology. Renal physiology 2009 (Fibrosis) : Furthermore, the PI3K antagonist, LY294002, reduced TGF-beta1 stimulated COL1A2 promoter activity and Rac1 activation
Greenwel et al., Mol Cell Biol 1995 : Our experiments have shown that TGF-beta 1 stimulates COL1A2 transcription by increasing binding of an Sp1 containing complex ( TbRC ) to the TbRE