◀ Back to TGFB1

SMC3 — TGFB1

Text-mined interactions from Literome

Kawai-Kowase et al., Arterioscler Thromb Vasc Biol 2004 : In the presence of bFGF, TGFbeta1 induction of SMC marker gene expression was significantly attenuated ... Mitogen activated protein kinase kinase-1 ( MEK1 ) inhibitor PD98059 abrogated the bFGF mediated suppression of TGFbeta1 induced SMC gene expression ... Our data suggest that bFGF induced MEK/extracellular signal regulated kinase signaling plays an antagonistic role in TGFbeta1 induced SMC gene expression through suppression of the SRF function ... These data indicate that opposing effects of bFGF and TGFbeta1 on SMC gene expression control the phenotypic plasticity of SMCs
Deaton et al., J Biol Chem 2005 : TGF-beta1 stimulated actin re-organization, inhibited cell proliferation, and up-regulated SMC marker gene expression in PAC-1 SMCs ... RNA interference mediated inhibition of PKN abolished TGF-beta1 induced activation of SMC marker gene promoters ... Finally, examination of MAPK signaling demonstrated that TGF-beta1 increased the activity of p38 MAPK, which was required for activation of the SMC marker gene promoters
Qiu et al., Biochem Biophys Res Commun 2006 : This study provides the first evidence showing that histone hyperacetylation of the SM22 promoter is a target of TGFbeta1 signaling, suggesting that modulation of histone acetylation is involved in the molecular mechanisms of TGFbeta1 regulated SMC gene transcription
Morishita et al., J Neurochem 2007 : In this study, we report that agonists for G protein coupled receptors ( GPCRs ), including endothelin, lysophosphatidic acid and carbachol, effectively promote the expression of SMC-specific proteins in the presence of transforming growth factor-beta ( TGF-beta )
Yin et al., Mol Nutr Food Res 2007 (Albuminuria...) : SEC or SMC intake significantly suppressed renal TGF-beta1 level and renal PKC activity ( P < 0.05 ) ; however, only SEC treatments showed dose dependent effect
Gong et al., J Biol Chem 1995 : Platelet derived growth factor ( PDGF BB ) and transforming growth factor beta 1 ( TGF-beta 1 ) at 10 ng/ml increased ScR activity in rabbit SMC ( by approximately 4- and 2-fold, respectively ) but not in human SMC
McCaffrey et al., Mol Biol Cell 1993 (Hyperplasia) : Despite the similarities in the production of TGF-beta 1, old SMC were refractory to inhibition by TGF-beta 1, whereas young SMC were markedly inhibited ( 80 % ) by low levels of TGF-beta 1 ( IC50 < 5 pg/ml )
Reddy et al., J Cell Physiol 1993 : Rapidly growing SMC and quiescent serum stimulated SMC were inhibited by TGF beta 1 with an ID50 of approximately 0.5 ng/ml and maximal inhibition was observed at 10 ng/ml TGF beta 1
Halloran et al., J Vasc Surg 1996 : Relatively little is known about TGF-beta 1 's effects on human arterial SMC ... TGF-beta 1 regulates SMC type I procollagen expression partly by inducing PDGF-A as a co-factor
Topouzis et al., Dev Biol 1996 : However, we found dramatic, lineage dependent differences in SMC responses to transforming growth factor-beta ( TGF-beta )