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EDN1 — RHOA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Clerk et al., Mol Cell Biol 2001
(Cardiomegaly) :
Endothelin 1 and phenylephrine ( both hypertrophic agonists ) induced rapid activation of endogenous Rac1, and endothelin 1 also
promoted significant activation of
RhoA
Zubkov et al., J Cardiovasc Pharmacol 2004
:
The following results were observed : ( 1 ) endothelin-1 produced phosphorylation of MAPK and RhoA and contraction by activation of endothelin-A but not endothelin-B receptors ; ( 2 ) MAPK inhibitors, PD 98059 and U0126, PTK inhibitor, genistein, Src kinase inhibitor, damnacanthal, and Janus tyrosine kinase ( JAK2 ) inhibitor, AG-490, abolished endothelin-1 induced contraction and MAPK immunoreactivity ; ( 3 ) PTK inhibitor, staurosporine, and phosphatidylinositol 3-kinase (PI- 3K) inhibitor wortmannin abolished endothelin-1 induced contraction but not MAPK immunoreactivity ; ( 4 ) Rho-kinase inhibitor, Y-27632, reduced endothelin-1 induced contraction ; ( 5 ) PI-3K inhibitor, wortmannin, but not PKC and PTK inhibitors, reduced
endothelin-1 induced
RhoA activation ; ( 6 ) endothelin-1 increased the level of myosin light chain ( MLC ) phosphorylation, and Rho-kinase inhibitor, Y-27632, reduced the effect of endothelin- 1 on MLC phosphorylation
Chiba et al., Eur J Pharmacol 2005
:
Endothelin-1 induced translocation of
RhoA is mediated by endothelin ET ( A ) receptors in rat bronchial smooth muscle ... To clarify the receptor subtype ( s ) contributing to the
RhoA activation by
endothelin-1 in bronchial smooth muscle, the effects of BQ-123 [ cycro ( D-Asp-Pro-D-Val-Leu-D-Trp ) ], an endothelin ET ( A ) receptor antagonist, and/or BQ-788 [ 2,6-dimethylpiperidinecarbonyl-g-methyl-Leu-Nin- ( Methoxycarbonyl ) -D-Trp-D-Nle ], an endothelin ET ( B ) receptor antagonist, on the endothelin-1 induced translocation of RhoA to plasma membrane were examined ... Incubation of rat bronchial smooth muscle with endothelin-1 induced a distinct translocation of RhoA to plasma membrane, indicating an
activation of
RhoA by
endothelin-1 ... The
endothelin-1 induced translocation of
RhoA was completely blocked by treatment with BQ-123, whereas BQ-788 had no effect ... Thus, endothelin ET ( A ) but not ET ( B ) receptors might be involved in the
endothelin-1 induced translocation of
RhoA in rat bronchial smooth muscle
Chiba et al., J Biochem 2005
(Bronchial Hyperreactivity) :
Changes in
endothelin-1 (ET-1) induced contraction and activation of
RhoA in bronchial smooth muscle of repeatedly antigen challenged rats, which exhibit marked airway hyperresponsiveness (AHR), were examined
Morishita et al., J Neurochem 2007
:
Whereas
endothelin consistently
activated RhoA , TGF-beta did not, and a specific inhibitor of TGF-beta type I receptor blocked TGF-beta enhanced SMA promoter activity, suggesting involvement of Smad phosphorylation
Homma et al., J Cardiovasc Pharmacol 2007
(Anoxia...) :
Endothelin-1 and serotonin are
involved in activation of
RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation
Nakaoka et al., J Mol Cell Cardiol 2010
(Cardiomegaly) :
In neonatal rat cardiomyocytes,
endothelin-1 (ET-1), a GPCR agonist, but not leukemia inhibitory factor (LIF), an IL-6 related cytokine,
induced RhoA activation and promotes alpha-SKA gene expression via RhoA
Ramachandran et al., Invest Ophthalmol Vis Sci 2011
:
Elevated cAMP led to an increase in the phosphorylation of RhoA at Ser188, to the inhibition of
endothelin-1 (ET-1) induced activation of
RhoA , and to the formation of stress fibers
Fleming et al., J Biol Chem 1996
:
Translocation of
RhoA was also
induced by
endothelin-1
Wang et al., Am J Physiol 1998
:
Immunoprecipitation and immunoblotting revealed one form of 21-kDa
Rho A that translocated from the cytosol to the membrane in
response to stimulation by either
endothelin ( 10 ( -7 ) M ) or ceramide ( 10 ( -7 ) M ) ( approximately 30 % increase at 30 s that was sustained at 4 min )