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CTNNB1 — PTH

Text-mined interactions from Literome

Tobimatsu et al., Endocrinology 2006 : Parathyroid hormone increases beta-catenin levels through Smad3 in mouse osteoblastic cells ... The transcriptional activity of transfected dominant-active beta-catenin was enhanced by PTH , an effect that was antagonized by cotransfection of a dominant negative Smad3 ... In conclusion, the data demonstrate that PTH stimulates osteoblast beta-catenin levels via Smad3, and that both PKA and PKC pathways are involved
Kakar et al., J Bone Miner Res 2007 (Disease Models, Animal...) : Analysis of the expression of potential mediators of PTH actions showed that PTH treatment significantly induced the expression of Wnts 4, 5a, 5b, and 10b and increased levels of unphosphorylated, nuclear localized beta-catenin protein, a central feature of canonical Wnt signaling
Inoue et al., J Cell Biochem 2009 : Role of Smad3, acting independently of transforming growth factor-beta, in the early induction of Wnt-beta-catenin signaling by parathyroid hormone in mouse osteoblastic cells ... Here, we examined which actions of Smad3 are TGF-beta independent in stimulating the osteoblast phenotype and PTH induced Wnt-beta-catenin signaling ... PTH induced total beta-catenin and reduced phosphorylated beta-catenin levels at 1, 6, and 24 h in mouse osteoblastic MC3T3-E1 cells ... Transient transfection of Smad3AAVA inhibited the PTH induction of total beta-catenin and reduction of phosphorylated beta-catenin levels at 6 and 24 h, but not at 1 h, indicating that the early effects occur independently of TGF-beta receptor signaling ... In conclusion, the present study indicates that PTH induces osteoblast beta-catenin levels via Smad3 independently of, and dependently on, TGF-beta in the early and later induction phases, respectively
Cheng et al., Circ Res 2010 (Arteriosclerosis...) : Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis