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CSE — MMP2

Text-mined interactions from Literome

Onoue et al., Eur J Biochem 2004 (Pulmonary Disease, Chronic Obstructive) : VIP, at 10 ( -7 ) m, reduced CSE stimulated MMP activity and caspase-3 activation
Ning et al., Am J Respir Cell Mol Biol 2007 (MAP Kinase Signaling System...) : In this study, we show that cigarette smoke extract (CSE) induced MMP-2 protein expression and increased MMP-2 gelatinase activity of normal lung fibroblasts ... The concomitant MT1-MMP expression and MMP-2 activation by CSE are inhibited by EGR-1 siRNA ... Chemical inhibitors of ERK1/2 MAPK, but not of p38 and JNK, decreased CSE induced EGR-1 protein expression and MMP-2 activity of fibroblasts ... The identification that induction of MMP-2 and MT1-MMP by CSE from lung fibroblasts is EGR-1 dependent reveals a molecular mechanism for matrix remodeling in cigarette smoke related emphysema
Toegel et al., Genes & nutrition 2012 : In addition, the direct effect of CSE on the proteolytic activities of MMP-2 was evaluated using gelatin zymography ... We further observed that the levels of IL1ß induced MMP-1, MMP-3 , MMP-7, and MMP-9 mRNA, but not TIMP mRNA levels, were down-regulated in chondrocytes in response to CSE
Yang et al., J Mol Cell Cardiol 2012 (Neointima) : CSE deficiency also enhanced matrix metalloproteinase-2 (MMP-2) expression, and the selective blocking of MMP-2 decreased KO-SMC migration