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IGF1R — IL6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of IGF1R-IL6R → IL6 (increases) Ishikawa et al., J Clin Exp Hematop 2006*
  Evidence: Accordingly, under the cellular context of the elevated expression of IL- 6Ra on myeloma cells, it is assumed that IL-6Ra molecules are located close to IGF-I receptors at lipid rafts, and IL-6 stimulation triggers the complex formation of IL-6Ra not only with gp130 but also with IGF-I receptors, leading to autophosphorylation of IGF-I receptor b and subsequent acti- vation of PI-3 kinase-Akt pathways (Fig. 4) 79 .

Text-mined interactions from Literome

Anwar et al., Circulation 2002 (Arteriosclerosis) : IL-1beta, IL-6 , and IFN-gamma did not regulate IGF-1, IGF-1 receptor (R) , or IGF binding proteins ( IGFBPs )
Sprynski et al., Blood 2009 (Multiple Myeloma...) : IGF-1 was the major one : its activity was abrogated by an IGF-1R inhibitor only, whereas IL-6 , HGF, or HB-EGF activity was inhibited by both IGF-1R- and receptor-specific inhibition