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IL6 — PGD

Text-mined interactions from Literome

Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 1999 : In the present study, we investigated the effect of PGD2 on the synthesis of interleukin-6 (IL-6) and its regulatory mechanism in MC3T3-E1 cells ... PGD2 significantly stimulated IL-6 synthesis dose-dependently in the range between 10 nM and 10 microM ... The depletion of extracellular Ca2+ by EGTA reduced the PGD2 induced IL-6 synthesis ... TMB-8, an inhibitor of intracellular Ca2+ mobilization, significantly inhibited the PGD2 induced IL-6 synthesis ... On the other hand, calphostin C, a specific inhibitor of protein kinase C ( PKC ), enhanced the synthesis of IL-6 induced by PGD2 ... In addition, U-73122, an inhibitor of phospholipase C, and propranolol, a phosphatidic acid phosphohydrolase inhibitor, enhanced the PGD2 induced IL-6 synthesis ... These results strongly suggest that PGD2 stimulates IL-6 synthesis through intracellular Ca2+ mobilization in osteoblasts, and that the PKC activation by PGD2 itself regulates the over-synthesis of IL-6
Peeraully et al., Pflugers Arch 2006 : In contrast, PGD ( 2 ) induced a marked stimulation of IL-6 and MCP-1 expression ; with IL-6, this was rapid, the mRNA level increasing by > 50-fold by 1 h
Tokuda et al., Prostaglandins Leukot Essent Fatty Acids 2008 : In the present study, we investigated whether Rho-kinase is implicated in the PGD2 stimulated IL-6 synthesis in MC3T3-E1 cells ... Y27632, a specific Rho-kinase inhibitor, significantly reduced the PGD2 stimulated IL-6 synthesis as well as the MYPT-1 phosphorylation ... Fasudil, another inhibitor of Rho-kinase, suppressed the PGD2 stimulated IL-6 synthesis ... The PGD2 stimulated IL-6 synthesis was reduced by PD98059, a MEK inhibitor, and SB203580, an inhibitor of p38 mitogen activated protein ( MAP ) kinase, but not SP600125, an inhibitor of stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) ... In addition, PGD2 additively induced IL-6 synthesis in combination with endothelin-1 which induces IL-6 synthesis through p38 MAP kinase regulated by Rho-kinase