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CTGF — SRC

Text-mined interactions from Literome

Graness et al., Kidney Int 2006 : Interference with Src activity by PP2 had no effect on the morphological alterations but decreased tyrosine phosphorylation of focal adhesion proteins and almost completely prevented upregulation of CTGF ... On the other hand, when the fibroblasts were cultured on a rigid matrix, that is collagen coated plates, strong focal complexes prevented the dynamic alterations, and RhoA mediated upregulation of CTGF expression was independent of Src-FAK signaling
Zhang et al., J Cell Physiol 2010 : In this study we demonstrate that TGF-beta1 activates Src kinase in ROS17/2.8 cells and that treatment with the Src family kinase inhibitor PP2 prevents Src activation and CTGF induction by TGF-beta1
Kim et al., Mol Cell Biochem 2012 (Burns...) : In the presence of inhibitors of PI3K, Src , Smad, or reactive oxygen species, the effect of NRG1 on CTGF expression decreased significantly ... Taken together, our results suggest that NRG1 is involved in fibrotic scar pathogenesis via PI3K- or Src mediated CTGF expression