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IL2 — SOCS3
Pathways - manually collected, often from reviews:
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SOCS3
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
SOCS3
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
(modification, inhibits)
-
BioCarta il-2 receptor beta chain in t cell activation:
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
→
SOCS3
(modification, activates)
-
BioCarta il-2 receptor beta chain in t cell activation:
SOCS3
→
IL-2/IL-2R-alpha/IL-2R-beta/IL-2R-gamma/JAK1/JAK3 complex (IL2RB-JAK1-IL2RA-IL2RG-JAK3-IL2)
(modification, inhibits)
-
NCI Pathway Database IL2-mediated signaling events:
IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3)
→
IL2 (IL2)
(modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3/SHC/GRB2/SOS1/GAB2 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3-SHC1-GRB2-SOS1-GAB2)
→
SOCS3/RasGAP complex (SOCS3-RASA1)
(modification, activates)
Romero et al., EMBO J 1999, Cacalano et al., Nat Cell Biol 2001, Satoh et al., J Biol Chem 1992, Graves et al., J Immunol 1992, Nelms et al., Immunity 1998
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL2-mediated signaling events:
IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3)
→
IL2/IL2R alpha/beta/gamma/JAK1/LCK/JAK3 complex (IL2RA-IL2RB-IL2RG-IL2-JAK1-LCK-JAK3)
(modification, inhibits)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
Text-mined interactions from Literome
Cohney et al., Mol Cell Biol 1999
:
Here we report
SOCS-3 expression in
response to
IL-2 in both T-cell lines and human peripheral blood lymphocytes ... The findings suggest that when
SOCS-3 is rapidly
induced by
IL-2 in T cells, it acts to inhibit IL-2 responses in a classical negative feedback loop
Matsumoto et al., J Exp Med 2003
:
A
role of
suppressor of cytokine signaling 3 ( SOCS3/CIS3/SSI3 ) in CD28 mediated
interleukin 2 production
Yu et al., J Biol Chem 2003
:
Down-regulation of
SOCS3 expression is subsequently
followed by gradual increase in SOCS3 level and corresponding decline in
interleukin 2 (IL-2) secretion ... In fact, SOCS3 mRNA levels are inversely correlated with the amount of IL-2 secretion and proliferative responses of differentiating T-helper cells, suggesting mutually antagonistic effects of SOCS3 and
IL-2 and feedback
regulation of T-cell activation by
SOCS3
Owaki et al., J Immunol 2006
:
Forced expression of antisense
SOCS3 or dominant negative SOCS3 in the T cell line
blocked the IL-27 inudced inhibition of CD28 mediated
IL-2 production
Zhao et al., Clin Exp Immunol 2010
(Acute Disease...) :
IL-2 induced high
SOCS-3 expression in naive CD4 ( + ) T cells could inhibit polarization to Th1 with stimulation of allogeneic antigens ... We have demonstrated that
IL-2 induced high
SOCS-3 expression in naive CD4 ( + ) T cells could reduce the incidence of aGVHD between major histocompatibility complex ( MHC ) completely mismatched donor and host when high SOCS3 expression of CD4 ( + ) T cells encounter allogeneic antigen in time ... These results show that
IL-2 induced high
SOCS-3 expression can inhibit aGVHD through inhibiting proliferation and polarization to Th1 with the stimulation of allogeneic antigen
Kleinsteuber et al., Blood 2012
(Tuberculosis) :
SOCS3 promotes
interleukin-17 expression of human T cells
Romain et al., Arterioscler Thromb Vasc Biol 2013
(Aortic Aneurysm, Abdominal...) :
Overexpression of
SOCS3 in T lymphocytes
leads to impaired
interleukin-17 production and severe aortic aneurysm formation in mice -- brief report