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STK11 — TSC2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: TSC2 → STK11 (increases, STK11 Activity, TSC2 Activity) Foster et al., Cancer Res 2007*
  Evidence: TSC1/2 can also be targeted and activated by LKB1 tumor suppressor protein, activating the AMPdependent kinase
• WikiPathways Integrated Breast Cancer Pathway: STK11 → TSC2 (mim-stimulation)

Text-mined interactions from Literome

Shaw et al., Cancer Cell 2004 (Colonic Polyps...) : Here, we report that LKB1 is required for repression of mTOR under low ATP conditions in cultured cells in an AMPK- and TSC2 dependent manner, and that Lkb1 null MEFs and the hamartomatous gastrointestinal polyps from Lkb1 mutant mice show elevated signaling downstream of mTOR
McGee et al., J Physiol 2008 (Hypertrophy) : The phosphorylation of TSC2 , an upstream regulator of the TORC1 pathway, at the AMPK site ( Ser1345 ) was increased in response to overload, and this was not affected by LKB1 deficiency