Gene interactions and pathways from curated databases and text-mining

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CD4 — GP6

Text-mined interactions from Literome

Yachou et al., Biochem Biophys Res Commun 1999 : Binding of soluble recombinant HIV envelope glycoprotein , rgp120, induces conformational changes in the cellular membrane anchored CD4 molecule
Basmaciogullari et al., J Virol 2002 : Binding of the HIV-1 gp120 envelope glycoprotein to the chemokine receptors normally requires prior interaction with CD4
Gorse et al., Clinical and vaccine immunology : CVI 2006 (HIV Infections) : Mean frequencies of HIV-1 envelope glycoprotein stimulated , activated intra-cellular IFN-gamma producing CD4 ( + ) and CD8 ( + ) lymphocytes and of interleukin-2 producing CD4 ( + ) lymphocytes did not increase after vaccination, but cytokine producing cells were detectable in some patients
Rawat et al., Mol Membr Biol 2008 : These engineered cells are resistant to fusion mediated CD4 dependent HIV-1 envelope glycoprotein
Hu et al., J Immunol 2008 (HIV Infections) : We previously demonstrated that HIV envelope glycoprotein ( Env ), delivered in the form of a vaccine and expressed by dendritic cells or 293T cells, could suppress Ag-stimulated CD4 ( + ) T cell proliferation
Azevedo-Pereira et al., Acta Med Port 2008 (HIV Infections) : Binding of SU glycoprotein to CD4 molecule , enables HIV to adsorb to target cell membrane and also initiates conformational changes in SU glycoprotein that enable it to bind to a second receptor ( coreceptor )
Kassa et al., J Virol 2009 : Binding to the primary receptor CD4 induces conformational changes in the human immunodeficiency virus type 1 ( HIV-1 ) gp120 envelope glycoprotein that allow binding to the coreceptor ( CCR5 or CXCR4 ) and ultimately trigger viral membrane-cell membrane fusion mediated by the gp41 transmembrane envelope glycoprotein
Andersen et al., Scand J Immunol 1991 : Conglutinin binds the HIV-1 envelope glycoprotein gp 160 and inhibits its interaction with cell membrane CD4
Juszczak et al., J Biol Chem 1991 : Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes
Lay et al., J Biol Chem 2011 : The binding by HIV-1 gp120 to CD4 and a chemokine receptor activates the membrane fusion glycoprotein , gp41
Demaria et al., AIDS Res Hum Retroviruses 1996 : Soluble CD4 induces the binding of human immunodeficiency virus type 1 to cells via the V3 loop of glycoprotein 120 and specific sites in glycoprotein 41
Martin et al., Science 1997 : The gp120 envelope glycoprotein from human immunodeficiency virus strain HIV-1 ( YU2 ) bound human CCR5 ( CCR5hu ) or rhesus macaque CCR5 ( CCR5rh ) only in the presence of CD4
Sullivan et al., J Virol 1998 : CD4 Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein : consequences for virus entry and neutralization
Wang et al., J Biol Chem 1998 : The interaction of human immunodeficiency virus type 1 ( HIV-1 ) with CD4 and one of a cadre of chemokine receptors triggers conformational changes in the HIV-1 envelope ( Env ) glycoprotein that lead to membrane fusion
Sullivan et al., J Virol 1998 : Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies
Puri et al., Proc Natl Acad Sci U S A 1998 : The neutral glycosphingolipid globotriaosylceramide promotes fusion mediated by a CD4 dependent CXCR4 utilizing HIV type 1 envelope glycoprotein
Mavoungou et al., J Med Primatol 1998 (Monkey Diseases...) : Our results demonstrate that the soluble viral glycoprotein induce a specific phospholipase A2 (PLA2) activation in lymphocytes through CD4