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CDCA5 — TLR3
Text-mined interactions from Literome
Goriely et al., Blood 2006
:
Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and
TLR3 induced
IL-12p35 gene activation
Mäkelä et al., J Leukoc Biol 2009
(MAP Kinase Signaling System) :
DNA binding assays showed that
TLR3 and TLR8 stimulation
induced binding of multiple IFN regulatory factor ( IRF ) and STAT transcription factors to the
IL-12p35 gene promoter IFN stimulated response element in moDCs and macrophages but with different binding profiles and kinetics
Yew et al., Acta Virol 2011
:
In particular, Lyn kinase oligonucleotides resulted in decreased expression of TLR-9 induced tumor necrosis factor alpha ( TNF-a ) but strongly upregulated canonical TLR-3 induced interferon beta ( IFN-ß ) and non-canonical
TLR-3 induced NF-?B dependent
p35 ( 35kDa ) subunit of interleukin 12 ( IL-12p35 ) gene transcription