Gene interactions and pathways from curated databases and text-mining

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CR2 — TNF

Text-mined interactions from Literome

Gommerman et al., J Immunol 2000 (Acute Disease...) : Interestingly, early TNF-alpha release is also impaired in Cr2 ( null ) and CD19 ( null ) animals, suggesting that these molecules directly affect mast cell activation
Klimas et al., Am J Med Sci 1992 (Autoimmune Diseases...) : Analysis of the pleural effusion revealed an increased CD4/CD8 ratio because of an increased percentage of CD4+CD29+ helper memory T cells, lack of expression of the resting B-cell marker CD21 , immune complex deposition and complement consumption, increased relative levels of ANA, abnormally high levels of IL-6 and soluble IL-2R, and detectable levels of IL-1b, IFN-g and TNF-a
Frémeaux-Bacchi et al., Eur J Immunol 1998 : Soluble CD21 induced an increase in intracellular cGMP levels and the production of IL-6 and TNF-alpha in IL-4 pretreated monocytes induced to express CD23 but not in unstimulated CD23- monocytes