◀ Back to TNF
F2RL1 — TNF
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
F2RL1
→
TNF
(increases)
Evidence: Table 3 - Changes in expression of PARs in vascular endothelial cells and smooth muscle cells.
Text-mined interactions from Literome
Lang et al., Invest Ophthalmol Vis Sci 2003
:
HCE-T expression of cytokines ( IL-6, IL-8, and
TNFalpha ) in
response to activation of
PAR-1 and -2 was measured by quantitative RT-PCR and ELISA
Tae et al., Clin Chim Acta 2003
(Disease Models, Animal...) :
The AELJ ( 100 mg/kg ) also significantly inhibited
PAR2 agonists
induced myeloperoxidase (MPO) activity and
tumor necrosis factor (TNF)-alpha expression in paw tissue
Ebeling et al., J Allergy Clin Immunol 2005
(Inflammation...) :
PAR-2ap administered with allergen
increased TNF and IL-5 mRNA in lung tissue and IL-13 and TNF in bronchoalveolar lavage fluid
Ramachandran et al., Am J Physiol Lung Cell Mol Physiol 2007
:
Flow cytometry for PAR1, PAR2, and PAR3 also demonstrated selective
PAR2 upregulation in
response to
TNF-alpha and LPS ...
Upregulation of
PAR2 by
TNF-alpha heightened HPBF responses to trypsin, while PAR4 induction enabled cathepsin-G mediated calcium signaling
Ritchie et al., Br J Pharmacol 2007
(Calcium Signaling...) :
We investigated the
effects of
tumour necrosis factor-alpha (TNF-alpha) , interleukin-1beta (IL-1beta), trypsin and the PAR2 activating peptide, 2-furoyl ( 2f ) -LIGKV-OH on both mRNA and functional expression of
PAR2 in human umbilical vein endothelial cells ( HUVECs )
Amiable et al., Bone 2009
(Bone Resorption...) :
On OA osteoblasts,
PAR-2 production was significantly
increased by IL-1 beta,
TNF-alpha and PGE ( 2 )
Saito et al., Hum Reprod 2011
(Endometriosis...) :
Only TGF-ß1, but neither
TNF-a nor IL-1ß,
increased gene expression of
PAR2
Zhang et al., Cell Physiol Biochem 2012
(MAP Kinase Signaling System) :
Inhibition of
PAR-2 activation
reduced tryptase induced
TNF-alpha , IL-6 and ROS production, and mitochondrial membrane potential loss in microglia