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MAP2K4 — MAP3K5

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAP2K4 → MAP3K5 (directlyIncreases, MAP3K5 Activity, MAP2K4 Activity)
  Evidence: Glucose deprivation rapidly increases the interaction between ASK1 and JIP3, and the consequently activated ASK1 phosphorylates SEK1 on the Thr-261 residue.
• OpenBEL Selventa BEL large corpus: MAP2K4 → MAP3K5 (directlyIncreases, MAP2K4 Activity)
  Evidence: Glucose deprivation rapidly increases the interaction between ASK1 and JIP3, and the consequently activated ASK1 phosphorylates SEK1 on the Thr-261 residue.
• BioCarta keratinocyte differentiation: FAS L/FAS/DAXX/ASK1 complex (FASLG-FAS-DAXX-MAP3K5) → JNKK1 (MAP2K4) (modification, activates)
• Reactome Reaction: MAP3K5 → MAP2K4 (reaction) Matsuura et al., J Biol Chem 2002*, Ichijo et al., Science 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAP2K4 — MAP3K5 (physical association, affinity chromatography technology) Ryoo et al., J Biol Chem 2004*
• IRef Biogrid Interaction: MAP2K4 — MAP3K5 (direct interaction, enzymatic study) Song et al., J Cell Biochem 2004*
• IRef Biogrid Interaction: MAP2K4 — MAP3K5 (physical association, affinity chromatography technology) Kim et al., Cell Death Differ 2007*
• MIPS CORUM MKK4-ARRB2-ASK1 complex: MKK4-ARRB2-ASK1 complex complex (ARRB2-MAP2K4-MAP3K5) McDonald et al., Science 2000*
• IRef Corum Interaction: Complex of MAP3K5-ARRB2-MAP2K4 (association, coimmunoprecipitation) McDonald et al., Science 2000*
• IRef Hprd Interaction: Complex of ARRB2-MAP2K4-MAP3K5-MAP2K4-ARRB2-MAP3K5-MAP3K5-ARRB2-MAP2K4 (in vivo) McDonald et al., Science 2000*
• IRef Innatedb Interaction: MAP2K4 — MAP3K5 (unknown, -) Guo et al., J Biol Chem 2008*
• IRef Innatedb Interaction: MAP2K4 — MAP3K5 (unknown, -) Kim et al., Cell Death Differ 2007*

Text-mined interactions from Literome

Tu et al., Cell Signal 2003 : They consist of a three-kinase module in which a mitogen activated protein kinase kinase kinase ( MAP3K ) activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates MAPK
Huang et al., Biochem Biophys Res Commun 2003 : MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a mitogen activated protein kinase kinase ( MAP2K ), which in turn activates a mitogen activated protein kinase ( MAPK )