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CALM3 — RAF1

Text-mined interactions from Literome

Moretó et al., Cell Signal 2009 (MAP Kinase Signaling System) : Though inhibition of CaM , using the CaM antagonist W-13, significantly increased Raf-1 activation by K-Ras-GTP, MAPK activation downstream K-Ras/Raf-1 was strongly reduced in COS-1 and several other cell lines ... In contrast, in other cell lines such as NIH3T3-wt8, W-13 mediated inhibition of CaM increased Raf-1 activity, but resulted in an increase in MAPK phosphorylation
Yoshiki et al., Mol Biol Cell 2010 (Calcium Signaling) : Using a biosensor based on fluorescence resonance energy transfer, it was found that activation of Raf1 at the plasma membrane required not only Ras activation but also an increase in Ca ( 2+ ) concentration or inhibition of calmodulin ... These observations indicated that the Shoc2 scaffold protein modulates Ras dependent Raf1 activation in a Ca ( 2+ ) - and calmodulin dependent manner