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IL6 — SOCS1

Text-mined interactions from Literome

Dickensheets et al., Proc Natl Acad Sci U S A 1999 (Translocation, Genetic) : Forced expression of SOCS-1 in a macrophage cell line, RAW264, markedly suppressed trans-activation of an IL-4-inducible reporter as well as IL-6- and IFN-gamma induced reporter gene activity
Diehl et al., Immunity 2000 : IL-6 upregulates suppressor of cytokine signaling 1 ( SOCS1 ) expression in activated CD4+ T cells, thereby interfering with signal transducer and activator of transcription 1 ( STAT1 ) phosphorylation induced by interferon gamma (IFNgamma)
Li et al., J Invest Dermatol 2004 (Carcinoma in Situ...) : To check whether suppressors of cytokine signalling ( SOCS ) play a role in cytokine resistance and tumor progression of melanoma, we investigated the expression and regulation of SOCS-1 , an established negative regulator of interleukin-6 (IL-6) and interferon ( IFN ) signalling ... Both IL-6 and alpha-IFN induced rapid and transient SOCS-1 mRNA expression in WM35 and WM9 melanoma cells
Kimura et al., Proc Natl Acad Sci U S A 2005 : In this study, we demonstrate that SOCS-1 selectively inhibits LPS induced IL-6 production through regulation of JAK-STAT but not production of TNF-alpha, granulocyte colony stimulating factor, IFN-beta, and other cytokines
Lee et al., Mol Cancer Ther 2006 (Carcinoma, Squamous Cell...) : Suppressor of cytokine signaling-1 ( SOCS-1 ) has been implicated recently in the negative regulation of IL-6R/Janus activated kinase ( JAK ) -mediated activation of STAT3, suggesting that SOCS-1 could affect alternative activation of STAT3 by EGFR, IL-6R , and associated kinases ... We investigated whether epigenetic modification of SOCS-1 affects STAT3 activation in response to IL-6R- , EGFR-, JAK-, or mitogen activated protein kinase/extracellular signal regulated kinase kinase ( MEK ) -mediated signal activation
Kolliputi et al., Am J Respir Cell Mol Biol 2009 (Acute Lung Injury...) : Both IL-6 stimulated endogenous SOCS-1 and SOCS-1 overexpression abolished H ( 2 ) O ( 2 ) -induced ASK-1 activation
Prêle et al., J Immunol 2008 : In addition, SOCS1 regulated the production of IL-6 , but not IL-10, by monocytes
Neuwirt et al., Am J Pathol 2009 (Neoplasm Recurrence, Local...) : In LNCaP-interleukin-6- prostate cancer cells, SOCS-1 was up-regulated by interleukin-6 and in PC3-AR cells by androgens ; such up-regulation was also found to significantly impair cell proliferation
Görgün et al., Blood 2010 (Multiple Myeloma) : SOCS1 negatively regulates IL-6 signaling and is silenced by hypermethylation in MM cells
Shackleford et al., Breast Cancer Res 2011 (Breast Neoplasms) : We also analyzed whether the siRNA mediated inactivation of Stat3 and Src could reduce Jab1-promoter activity and whether interleukine-6 (IL-6) could mediate increased Jab1 expression through Stat3 signaling
Park et al., J Allergy Clin Immunol 2013 (Nasal Polyps...) : Nasal epithelial cell culture was used to elucidate the effect of IL-4, IL-5, IL-6 , IL-10, IL-13, IFN-?, TNF-a, and TGF-ß1 on SOCS1 and SOCS3 expression in sinus mucosa
Suzuki et al., Oncogene 1998 (Leukemia, Myeloid, Acute) : In M1 myeloid leukemia cells, CIS3 was induced by neither interleukin 6 (IL6) nor interferon gamma (IFNgamma), while JAB was induced strongly by IFNgamma and slightly by IL6 and leukemia inhibitory factor (ILF)
Nicholson et al., EMBO J 1999 : SOCS-1 and SOCS-3 inhibited both interleukin-6 (IL-6)- and leukemia inhibitory factor (LIF) induced macrophage differentiation of murine monocytic leukemic M1 cells and LIF induction of a Stat3-responsive reporter construct in 293T fibroblasts