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IL6 — STAT4

Text-mined interactions from Literome

Chin et al., Nature 2002 (Listeriosis...) : Furthermore, Rip2 deficiency results in impaired interferon-gamma production in both TH1 and natural killer cells, attributed in part to defective interleukin-12 induced Stat4 activation
Karpuzoglu et al., Endocrinology 2009 : Signal transducer and activation of transcription ( STAT ) 4beta, a shorter isoform of interleukin-12 induced STAT4 , is preferentially activated by estrogen
Watford et al., J Exp Med 2008 (Toxoplasmosis, Animal) : We investigated the potential roles of Tpl2 in T cells and found that it was induced by interleukin-12 in human and mouse T cells in a Stat4 dependent manner
Lin et al., Int J Cancer 2012 (Multiple Myeloma) : LLL12 also inhibited STAT3 phosphorylation induced by interleukin-6 (IL-6) and interferon-a but not STAT1, STAT2, STAT4 and STAT6 phosphorylation induced by interferon-a, interferon-? and IL-4 indicating the selectivity of LLL12 for STAT3
Wang et al., J Mol Med (Berl) 2013 : These effects, in turn, may be mediated by EGCG induced downregulation of transducers p-STAT1 and p-STAT4 for Th1, and p-STAT3 for Th17. EGCG induced change in Th17/Treg balance may be mediated by its inhibition of IL-6 signaling because EGCG inhibited soluble IL-6R, membrane gp130, and IL-6 induced phosphorylation of STAT3
Thierfelder et al., Nature 1996 : Requirement for Stat4 in interleukin-12 mediated responses of natural killer and T cells