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IKBKB — REL
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Bind Interaction:
Complex of 25 proteins
Bouwmeester et al., Nat Cell Biol 2004
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IRef Bind Interaction:
Complex of 11 proteins
Bouwmeester et al., Nat Cell Biol 2004
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IRef Bind Interaction:
Complex of FBXW7-NFKB2-REL-MAP3K14-USP2-RELA-IKBKG-IKBKB
Bouwmeester et al., Nat Cell Biol 2004
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IRef Bind Interaction:
Complex of IKBKB-IKBKAP-REL-NFKBIA-IKBKG-MCM5-NFKB2-MCM7-RELA
Bouwmeester et al., Nat Cell Biol 2004
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IRef Bind Interaction:
Complex of 21 proteins
Bouwmeester et al., Nat Cell Biol 2004
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MIPS CORUM TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2):
TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) complex (CHUK-FBXW7-IKBKB-IKBKG-MAP3K14-NFKB2-REL-RELA-SEC16A-USP2)
Bouwmeester et al., Nat Cell Biol 2004
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MIPS CORUM TNF-alpha/NF-kappa B signaling complex 5:
TNF-alpha/NF-kappa B signaling complex 5 complex (CD3EAP-CHUK-CUL1-FBXW11-IKBKB-IKBKG-IQGAP2-KPNA2-LRPPRC-MCC-MTIF2-NFKB1-NFKB2-NFKBIB-PDCD2-POLR1A-POLR1B-POLR1D-POLR1E-POLR2H-POLR2L-RASAL2-REL-RELA-SKP1)
Bouwmeester et al., Nat Cell Biol 2004
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IRef Corum Interaction:
Complex of 11 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Corum Interaction:
Complex of 26 proteins
(association, tandem affinity purification)
Bouwmeester et al., Nat Cell Biol 2004
-
IRef Hprd Interaction:
Complex of 101 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
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IRef Hprd Interaction:
Complex of 626 proteins
(in vivo)
Bouwmeester et al., Nat Cell Biol 2004
Text-mined interactions from Literome
Silverman et al., Genes Dev 2000
:
Remarkably, this Drosophila
IkappaB kinase complex is not
required for the activation of the
Rel proteins Dif and Dorsal through the Toll signaling pathway, which is essential for antifungal immunity and dorsoventral patterning during early development ... Thus, a yet to be identified
IkappaB kinase complex must be
required for
Rel protein activation via the Toll signaling pathway
Weber et al., Gastroenterology 2000
:
NF-kappaB/Rel activity
induced by tumor necrosis factor alpha, 12-O-tetradecanoylphorbol-13-acetate, or overexpression of NF-kappaB inducing kinase, IKK-alpha,
IKK-beta , or constitutively active IKK-alpha and IKK-beta mutants was inhibited dose dependently by sulfasalazine ...
NF-kappaB/Rel activity
induced by tumor necrosis factor alpha, 12-O-tetradecanoylphorbol-13-acetate, or overexpression of NF-kappaB inducing kinase, IKK-alpha,
IKK-beta , or constitutively active IKK-alpha and IKK-beta mutants was inhibited dose dependently by sulfasalazine
Garbati et al., Gene Expr 2008
:
Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro : evidence that
IKK does not directly
enhance GAL4-REL transactivation ... We also show that the previously reported effects of overexpressed IKK and tumor necrosis factor treatment on
GAL4-REL transactivation are
due to
IKK mediated activation of the endogenous NF-kappa B pathway, which increases transcription from kappa B sites in the promoter of a commonly used GAL4 expression vector