Yoshikawa et al., Neurochem Int 2010
:
Geldanamycin induced decrease of insulin receptor substrate-1 was attenuated by lactacystin, beta-lactone or MG132 ( proteasome inhibitor ), but not by calpastatin ( calpain inhibitor ) or leupeptin ( lysosome inhibitor ) ; geldanamycin did not affect heteroprotein complex formation between insulin receptor substrate-1 or -2 and Hsp90
Smith et al., Mol Cell Endocrinol 1996
:
Calpastatin ( specific calpain inhibitor protein ) also inhibited the insulin induced down-regulation of IRS-1 in transiently permeabilized cells