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IL6 — MMP3

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Shlopov et al., J Rheumatol 2001 (Osteoarthritis) : A decrease in IL-1alpha, IL-1beta, and IL-6 would reduce stimulation of MMP production, while an increase in TGF-83 would lead to downregulation of local proinflammatory cytokine production as well as of the collagenases themselves
Imafuku et al., Clin Chim Acta 2002 : We also found a definite effects on copper, angiotensin converting enzyme (ACE), matrix metalloproteinase (MMP)-1 , -3 and -9, tissue inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF), monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6 , though the mechanisms were not clear
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha), IL-6 , HGF, and 12-O-tetradecanoylphorbol 13-acetate
Bamba et al., J Gastroenterol 2003 : Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts : role of interleukin-17
Fleenor et al., Invest Ophthalmol Vis Sci 2003 : In the trabecular meshwork ( TM ), interleukin (IL)-1alpha is a potent inducer of MMP-3 expression
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Borghaei et al., Biochem Biophys Res Commun 2004 : A 5T/6T polymorphic site in the matrix metalloproteinase-3 (MMP-3) promoter has been identified as a repressor element involved in inhibiting induction of MMP-3 transcription by interleukin 1 ; and the 6T allele has been associated with decreased expression of MMP-3 as compared to the 5T allele
Inoue et al., Rheumatol Int 2005 (Osteoarthritis, Hip...) : Induction of vascular endothelial growth factor and matrix metalloproteinase-3 ( stromelysin ) by interleukin-1 in human articular chondrocytes and synoviocytes
Park et al., J Invest Dermatol 2004 (MAP Kinase Signaling System) : The specific inhibition of IL-6 using a monoclonal antibody against IL-6 greatly reduced the expression of MMP-1 and MMP-3 induced by heat shock
Legendre et al., J Rheumatol 2005 (MAP Kinase Signaling System) : IL-6/sIL-6R markedly induced activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3, an aggrecan degrading enzyme and activator of pro-MMP ... IL-6/sIL-6R markedly induced activation of STAT and extracellular signal related kinase ( ERK1/2 ) and the subsequent expression of the collagenases MMP-1 and MMP-13 as well as MMP-3 , an aggrecan degrading enzyme and activator of pro-MMP
Chen et al., Ann Neurol 2006 (Intracranial Arteriovenous Malformations) : IL-6 induced MMP-3 and MMP-9 expression and activity in mouse brain and increased proliferation and migration of cerebral endothelial cells
Previti et al., Journal of neuroinflammation 2006 : Our results suggest that although dexamethasone has no appreciable consequence on HCSM cell surface fibrillar Abeta accumulation it effectively reduces the subsequent pathologic responses including elevated levels of IL-6 , MMP-2 activation , and depletion of HCSM alpha actin
Stewart et al., BMC molecular biology 2007 : Interleukin-4 inhibition of interleukin-1 induced expression of matrix metalloproteinase-3 (MMP-3) is independent of lipoxygenase and PPARgamma activation in human gingival fibroblasts
Chang et al., Rheumatol Int 2007 (Chondrosarcoma) : Activin A suppresses interleukin-1 induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells
Lee et al., Scand J Rheumatol 2008 (Arthritis, Experimental) : TNFalpha, IL-1beta, and MMP-3 expression decreased, but IL-6 expression in AD-treated joint tissues increased
Li et al., J Cell Biochem 2010 (MAP Kinase Signaling System) : Although it is known that interleukin (IL)-6 is a key proinflamatory cytokine, it remains unclear how IL-6 regulates MMP expression by mononuclear phagocytes ... Furthermore, it remains undetermined how IL-6 in combination with hyperglycemia affects MMP expression
Suzuki et al., Cytokine 2010 (MAP Kinase Signaling System) : IL-6+sIL-6R, but not IL-6 alone, induced MMP-13 and MMP-3 production
Wang et al., J Biol Chem 2010 : Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1 induced matrix metalloproteinase-3 expression
Clérigues et al., Biochem Pharmacol 2012 (Osteitis...) : HO-1 induction significantly reduced the expression of matrix metalloproteinase (MMP)-1, MMP-2 and MMP-3 , and the production of pro-inflammatory cytokines such as tumor necrosis factor-a and IL-6 whereas IL-10 levels increased
Nakamura-Shibasaki et al., Cell Biochem Funct 2013 : Depletion of IL-6 by RNA interference in cells isolated after filtration surgery increased the expression of MMP-1 and MMP-3 in these cells ... These results thus suggest that the expression of MMP-1 and MMP-3 in Tenon fibroblasts is regulated by IL-6 during, and may play an important role in, scar formation after glaucoma surgery
Gotoh et al., Connect Tissue Res 2013 : Extracellular ß-NAD ( + ) inhibits interleukin-1 induced matrix metalloproteinase-1 and -3 expression on human gingival fibroblasts
Mann et al., Ann Otol Rhinol Laryngol 1995 (Carcinoma, Squamous Cell...) : Supernatants of HNSCC cell lines SCC-25 and FADU stimulated with interleukin (IL)-1 alpha and IL-1 beta demonstrated modest induction of 92 kd GL production by zymogram analysis when compared with controls ; IL-2, IL-6 , and interferon-gamma had no consistent effect on MMP production
Richards et al., J Immunol 1993 (Neoplasms) : The results suggest that OM as well as IL-6 and LIF, other cytokines acting through similar receptor pathways, may act to inhibit net MMP activity by specifically up-regulating TIMP-1 expression