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ARHGEF18 — RAC1

Pathways - manually collected, often from reviews:

• Reactome Reaction: ARHGEF18 → RAC1 (reaction) Harrington et al., J Neurosci 2002

Text-mined interactions from Literome

Niu et al., Circ Res 2003 : Using in vivo pull-down assays and dominant negative mutants of Rho GTPases, we have determined that p114RhoGEF activated RhoA and Rac1 but not Cdc42 proteins ... In summary, our data showed that the novel guanine nucleotide exchange factor p114RhoGEF regulates the activity of RhoA and Rac1 , and that Gbetagamma subunits of heterotrimeric G proteins are activators of p114RhoGEF under physiological conditions
Terry et al., PloS one 2012 : Accordingly, depletion of p114RhoGEF led to reduced RhoA, but increased Rac activity