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CDKN1A — NAB2
Text-mined interactions from Literome
Dai et al., Cell cycle (Georgetown, Tex.) 2003
:
Finally, the NF-kappaB inhibitor CAPE antagonized
NaB- and PMA related NF-kappaB DNA binding as well as
induction of
p21CIP1 ... Together, these findings suggest that NF-kappaB plays an important functional role in mediating
NaB induced
p21CIP1 induction, G1 arrest, and maturation in human myelomonocytic leukemia cells, and that disruption of the NF-kappaB pathway causes cells to engage an alternative, apoptotic program
Kobayashi et al., Nutr Cancer 2003
(Adenocarcinoma...) :
In all cell lines, p21 mRNA levels were immediately elevated after NaB exposure, and p21 protein levels were increased within 6 h.
NaB increased
p21 promoter activity in both Caco2 and Lovo, suggesting p53 independence
Li et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004
(Myelodysplastic Syndromes) :
The results showed that NaB and/or ATRA blocked cells mainly in the G0/G1 phase of the cell cycle ; ATRA inhibited the mRNA expression of CDK6, CDK4, cyclin D3 and cyclin D1 ; NaB inhibited the mRNA expression of CDK2, cyclin D2 and cyclin D1 ; ATRA and NaB inhibited the mRNA expression of CDK6, CDK4, CDK2, cyclin D1, cyclin D2 and cyclin D3 ; ATRA and/or
NaB both
stimulated p21 expression at the mRNA levels
Khasnavis et al., J Neuroimmune Pharmacol 2012
(Parkinson Disease) :
Together, these results suggest that
NaB upregulates DJ-1 via modulation of mevalonate metabolites and that p21(ras), but not
p21 ( rac ), is
involved in the regulation of DJ-1
Qu et al., J Cell Biol 1998
:
Furthermore,
NAB2 overexpression
led to downregulation of
p21 ( WAF1 ), a molecule previously shown to play a pivotal role in the ability of PC12 cells to undergo growth arrest and commit to differentiation in response to NGF