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BMP2 — IHH

Text-mined interactions from Literome

Kameda et al., Genes Cells 1999 : Developmental patterning in chondrocytic cultures by morphogenic gradients : BMP induces expression of indian hedgehog and noggin ... We also showed that retrovirally induced BMP-2 induces the expression of both Ihh and Noggin ( encoding the BMP inactivating protein ), and we further present evidence that a negative-feedback loop involving Noggin might account for the precise localization of BMP signalling for Ihh induction
Yoshida et al., Exp Cell Res 2001 : Retinoic acid ( RA ) and bone morphogenetic protein-2 enhanced Ihh mRNA expression, whereas PTH/PTH related peptide (PTHrP) markedly suppressed Ihh expression
Vortkamp et al., Osteoarthritis Cartilage 2001 : Alternatively BMP signalling, induced by Ihh , might reciprocally act back on the prehypertrophic chondrocytes, thereby coordinating hypertrophic differentiation with the differentiation of the periosteum
Minina et al., Dev Cell 2002 (Hypertrophy) : We furthermore found that FGF and BMP signaling act in an antagonistic relationship regulating chondrocyte proliferation, Ihh expression, and the process of hypertrophic differentiation
Zhang et al., J Bone Miner Res 2003 : The findings show that BMP signaling induces Ihh
Ionescu et al., J Cell Physiol 2004 : Dominant negative CREB reduced BMP-2 stimulated Smad6 gene transcription by 50 %, but markedly increased BMP-2 mediated stimulation of colX and Ihh expression ... In contrast, PTHrP which activates CREB signaling, blocked the stimulatory effect of BMP-2 on colX and Ihh , but minimally inhibited the stimulatory effect of BMP on Smad6 ... In contrast, PTHrP which activates CREB signaling, blocked the stimulatory effect of BMP-2 on colX and Ihh , but minimally inhibited the stimulatory effect of BMP on Smad6
Katoh et al., Int J Mol Med 2006 (Stomach Neoplasms) : BMP-RUNX3 signaling induces IHH expression in surface differentiated epithelial cells of stomach and intestine
Katoh et al., Cancer Biol Ther 2007 (Helicobacter Infections...) : Helicobacter pylori infection induces SHH upregulation in parietal cell lineage, while BMP signals induce IHH upregulation in pit cell lineage
Katoh et al., Stem Cell Rev 2007 (Disease Progression...) : BMP signals induce IHH upregulation in co-operation with RUNX
Katoh et al., Int J Oncol 2009 : Mesenchymal BMP induces IHH expression in gastrointestinal epithelial cells, and then epithelial Hedgehog induces WNT2B and BMP4 expression in mesenchymal cells
Lenton et al., Genesis 2011 : Moreover, in vitro studies suggest that Ihh loss reduces Bmp expression within the calvaria, an observation that may underlie the Ihh-/- calvarial phenotype
Murakami et al., Endocrinology 1997 (Osteosarcoma) : In sharp contrast to the previous observation of dpp regulation of hedgehog expression in Drosophila embryos, bone morphogenetic protein-2 did not affect Ihh expression in these cells