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FAS — NFKB1
Text-mined interactions from Literome
Chan et al., Mol Cell Biol 1999
:
Activation dependent transcriptional regulation of the human
Fas promoter
requires NF-kappaB p50-p65 recruitment
Hsing et al., J Immunol 1999
:
Surprisingly, up-regulation of
Fas , CD23, and ICAM-1 was partially independent, and up-regulation of LFA-1 was completely
independent , of CD40 induced
NF-kappaB activation
Dudley et al., Eur J Immunol 1999
:
NF-kappaB regulates
Fas/APO-1/CD95- and TCR- mediated apoptosis of T lymphocytes
Lee et al., J Immunol 2000
:
STAT-1alpha and
NF-kappaB activation are
involved in IFN-gamma- or TNF-alpha mediated
Fas up-regulation in microglia, respectively
Li-Weber et al., Eur J Immunol 2000
:
We show that both elements bind to NF-kappaB and SP-1 transcription factors and
NF-kappaB is
involved in transactivation of the
CD95L promoter upon T cell activation
Trauzold et al., Oncogene 2001
(Adenocarcinoma...) :
We report here that the stimulation of the
CD95- and TRAIL-resistant human pancreatic adenocarcinoma cell line PancTuI with an agonistic anti-CD95 antibody or TRAIL
resulted in activation of protein kinase C and
NF-kappaB ... Inhibition of protein kinase C by Gö6983 sensitized these cells to apoptotic challenges and strongly diminished
activation of
NF-kappaB by
anti-CD95 and TRAIL
Chakraborty et al., Cancer Res 2001
(Neoplasms, Hormone-Dependent...) :
Neither
Fas pathway activation alone nor
inhibition of
NF-kappaB activity with IkappaB-super repressor was sufficient to induce apoptosis of prostate cancer cells
Afford et al., FASEB J 2001
(Liver Cirrhosis, Biliary) :
CD40 activation induced,
Fas dependent apoptosis and
NF-kappaB/AP-1 signaling in human intrahepatic biliary epithelial cells
Russo et al., Am J Physiol Cell Physiol 2002
:
Differential requirement for NF-kappaB inducing kinase in the
induction of
NF-kappaB by IL-1beta, TNF-alpha, and
Fas
Scheller et al., Eur J Immunol 2002
(Inflammation...) :
Further analysis with A3.01 T cells revealed that the proinflammatory signaling activity of
CD95 was
mediated by MEK/ERK, p38 and
NF-kappaB signaling pathways
Qin et al., J Immunol 2002
(Leukemia, Myeloid, Acute) :
Fas resistance of leukemic eosinophils is due to
activation of
NF-kappa B by
Fas ligation ... Although
activation of
NF-kappaB by ligation of
Fas ( CD95/Apo-1 ), a member of the TNFR family, has been observed in a few studies, Fas mediated NF-kappaB activation has not previously been shown to protect cells from apoptosis ... We examined the
Fas induced
NF-kappaB activation and its antiapoptotic effects in a leukemic eosinophil cell line, AML14.3D10, an AML14 subline resistant to Fas mediated apoptosis
Malewicz et al., J Biol Chem 2003
:
In addition,
NF kappa B downstream of TNFR was
required for up-regulation of
Fas expression by endogenous TNF secreted in response to TCR stimulation
Okano et al., Oncol Rep 2003
(Carcinoma, Hepatocellular) :
Fas stimulation
activates NF-kappaB in SK-Hep1 hepatocellular carcinoma cells ... However, the
role of
Fas in induction of
NF-kappaB activation in HCC cells is not well understood ...
Fas stimulation
induced NF-kappaB activation in a dose dependent manner in SK-Hep1 and HepG2 cell lines, but not in HLE cells
El-Guendy et al., Mol Cell Biol 2003
:
Interestingly, a 59-amino-acid core that included NLS2 but not the C-terminal leucine zipper domain was necessary and sufficient to induce
Fas pathway activation,
inhibition of
NF-kappaB activity, and apoptosis
Lagunoff et al., Int Rev Immunol 2003
:
Virally encoded genes inhibit the activation of caspase-8 by the TNF receptor and
Fas ; activate
NF-kappaB to
increase expression of antiapoptotic genes ; inhibit interferon response ; bind to p53, thereby blocking p53 dependent apoptosis ; and interact with other pro- and antiapoptotic cellular genes
Watabe et al., J Biol Chem 2004
:
Caffeic acid phenethyl ester induces apoptosis by inhibition of
NFkappaB and
activation of
Fas in human breast cancer MCF-7 cells ... Our findings demonstrate that NFkappaB inhibition is sufficient to induce apoptosis and that
Fas activation
plays a role in
NFkappaB inhibition induced apoptosis in MCF-7 cells
Fujita et al., Oral Oncol 2004
(Carcinoma, Squamous Cell...) :
Our results suggest that
NF-kappaB activated at early stages in the okadaic acid treated SCC-25 cells
stimulated the promoter activity of
Fas receptor in the cells leading to the apoptotic death of these cells
Meli et al., Ann N Y Acad Sci 2003
(Lymphoma, T-Cell) :
Overall, these data suggest that
NF-kappaB inhibition may
restore the
Fas-pathway in Fas-resistant NF-kappaB overexpressing tumors
Suzuki et al., Infect Immun 2004
:
However, endogenous tumor necrosis factor alpha- and
Fas induced signals, extracellular signal regulated kinase kinase/mitogen activated protein kinases and I-kappa B
alpha/nuclear factor-kappa B (NF-kappa B) were not required for caspase-3 dependent apoptosis
Suhara et al., Hypertension 2004
(Arteriosclerosis) :
Hcy increased
NF-kappaB DNA binding activity, and adenovirus mediated transfection of a Ikappa-B mutant ( Ikappa-B mt ) gene
inhibited Hcy induced
Fas expression
Wurzer et al., J Biol Chem 2004
:
NF-kappaB dependent induction of tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and
Fas/FasL is crucial for efficient influenza virus propagation
Sinha et al., J Biol Chem 2004
(Insulin Resistance) :
We conclude that
FAs induce insulin resistance and
activates NFkappaB in L6 cells
Kreuz et al., J Cell Biol 2004
:
NFkappaB activation by
Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP ... Remarkably, the enzymatic activity of the latter was dispensable for
Fas induced
NFkappaB signaling pointing to a scaffolding related function of caspase-8 in nonapoptotic Fas signaling
Wiener et al., Exp Cell Res 2004
(Carcinoma, Non-Small-Cell Lung...) :
Synergistic
induction of the
Fas ( CD95) ligand promoter by Max and
NFkappaB in human non-small lung cancer cells
Legembre et al., Cell cycle (Georgetown, Tex.) 2004
(Neoplasms) :
In fact overexpression of apoptosis inhibitors such as Bcl-2 or c-FLIPL in these cells results in decreased
activation of
NF-kappaB through
CD95
Legembre et al., EMBO Rep 2004
:
Induction of apoptosis and
activation of
NF-kappaB by
CD95 require different signalling thresholds
Starace et al., FASEB J 2005
:
We studied the
role of the transcription factor
NF-kappaB and of MAPKs in regulating
Fas expression
Wu et al., J Bone Miner Res 2005
(Bone Resorption) :
The
involvement of
NF-kappaB in the regulation of
Fas by RANKL was analyzed by luciferase assay and EMSA
Vega et al., Oncogene 2005
(Burkitt Lymphoma...) :
The
involvement of
NF-kappaB and YY1 in the regulation of
Fas expression was corroborated by the use of Ramos cells with a dominant-active inhibitor of NF-kappaB ( Ramos IkappaB-estrogen receptor ( ER ) mutant ) and by silencing YY1 with YY1 siRNA, respectively
Le Clorennec et al., Blood 2006
(Cell Transformation, Viral...) :
Epstein-Barr virus ( EBV ) induces CD95 expression and the
CD95 gene ( FAS ) is
regulated by
NF-kappaB , STAT1, and/or p53
Maksimow et al., J Leukoc Biol 2006
:
Fas costimulation of naive CD4 T cells is
controlled by
NF-kappaB signaling and caspase activity
Packham et al., Cell Death Differ 1997
:
Fas activates
NF-kappaB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-alpha ... Surprisingly,
Fas induced signaling also
triggered the activation of
NF-kappaB in T cells, yet the kinetics of NF-kappaB induction by Fas was markedly delayed
Lee et al., EMBO J 2006
:
In contrast, CD95 ligand stimulation of cells unable to internalize
CD95 results in activation of proliferative Erk and
NF-kappaB signaling pathways
Wong et al., Clin Immunol 2006
:
Fas ( CD95 ) ligation
inhibits activation of
NF-kappa B by targeting p65-Rel A in a caspase dependent manner
Wang et al., Asian J Androl 2006
:
NF-kappa B is
activated by increased
FasL/Fas in CORT induced Leydig cell apoptosis
Wosik et al., J Neurol Sci 2007
:
TNFR1 ligation
induces NFkappaB activation and the upregulation of chemokines MCP-1 and IL-8, as well as adhesion molecules ICAM-1 and VCAM-1, while
Fas and DR5 triggering activate the extracellular signal regulated kinases-1 and -2 ( Erk 1/2, p42/44 MAPK ) inducing the release of matrix metalloproteinase 9 (MMP9) by BBB derived ECs
Pan et al., Int J Oncol 2007
(Bile Duct Neoplasms...) :
The inverse activities of
Fas and FasL promoter in tumor cells are
regulated by
NF-kappaB , which inhibits Fas expression and increases FasL expression through binding to their respective promoters
Motadi et al., Int Immunopharmacol 2007
(Carcinoma...) :
Of the several molecular targets, those receiving attention are p53 gene replacement, Bcl-2 downregulation, apoptosis by induced by TNF, the
FAS/CD95 receptor system and TRAIL, and
inhibition of
NF-kappaB
Le Clorennec et al., J Virol 2008
:
Therefore, our results are in agreement with a model where LMP1 dependent
NF-kappaB activation
induces Fas overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-kappaB, revealing an ambivalent function of LMP1 in cell survival and programmed cell death
Neumann et al., Molecular systems biology 2010
:
We established an integrated kinetic mathematical model for
CD95 mediated apoptotic and
NF-kappaB signaling
Ehrenschwender et al., Cell Death Differ 2010
(Neoplasm Invasiveness) :
In mutant PIK3CA expressing cells, tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) and
CD95L stimulated
nuclear factor kappaB (NFkappaB) activation, invasion, and transition to an amoeboid-like morphology
Schulze-Osthoff et al., EMBO J 1994
:
Whereas transcription factor
NF-kappa B was readily activated by TNF, activation was not
induced by triggering
APO-1/Fas
Rensing-Ehl et al., J Inflamm 1995
:
With regard to their cytoplasmic homology region, we investigated whether
Fas like the TNF-R
activates nuclear factor kappa B (NF-kappa B) , using human SV80 fibroblasts transfected with the cDNA encoding human Fas
Ravi et al., Cancer Res 1998
:
We demonstrate that ligation of
CD95 ( Fas/APO1 ), a potent apoptotic stimulus in lymphocytes,
results in repression of
NF-kappaB activity in Jurkat T cells by inducing the proteolytic cleavage of NF-kappaB p65 ( Rel A ) and p50
Bauer et al., J Biol Chem 1998
:
Moreover, inhibition of
NF-kappaB activity by a transdominant IkappaB mutant
attenuated CD95L expression
Grammer et al., J Immunol 1998
(Burkitt Lymphoma) :
By contrast, induction of apoptosis,
activation of
NF-kappaB , generation of granulocyte-macrophage CSF, and up-regulation of CD54, MHC class II, and
CD95 were unaffected by the TRAF3 dominant negative
Giardina et al., Biochim Biophys Acta 1999
(Colorectal Neoplasms) :
Cell death does correlate with alterations in NF-kappa B activity : the NSAIDs, butyrate and H2O2 enhance c-Rel complex formation by TNF-alpha and provide an overall enhancement of
NF-kappa B activation by
Fas