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MUC2 — NFKB1

Text-mined interactions from Literome

Ahn et al., Cell Physiol Biochem 2005 : Wortmannin, LY294002 and dominant negative Akt, as well as dominant negative NF-kappaB inducing kinase (NIK) inhibited MUC2 reporter transcription, indicating that both phosphatidylinositol-3-OH kinase (PI3K)/Akt signaling pathway and NIK pathways mediate the effects of TNF-alpha ... However, the existence of this inhibitory JNK pathways suggests a mechanism whereby -- in the absence of NF-kappaB activation -- TNF-alpha production during inflammation in vivo could actually inhibit MUC2 production, giving rise to the defective mucosal protection which characterizes inflammatory bowel disease
Fujisawa et al., J Immunol 2009 : NF-kappaB activation in airway epithelial cells has been shown to play a positive inflammatory role in chronic airway diseases ; however, the role of NF-kappaB in mucin gene expression is unresolved
Li et al., Proc Natl Acad Sci U S A 1998 (Cystic Fibrosis...) : Activated NF-kappaB binds to a kappaB site in the 5'-flanking region of the MUC2 gene and activates MUC2 mucin transcription ... Activated NF-kappaB binds to a kappaB site in the 5'-flanking region of the MUC2 gene and activates MUC2 mucin transcription