Gene interactions and pathways from curated databases and text-mining

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EGF — NOX4

Text-mined interactions from Literome

Frank et al., Endocrinology 2000 : In the presence of a NADH/NADPH oxidase inhibitor, diphenyleneiodonium ( DPI ) or an antioxidant, alpha-tocopherol, Ang II-induced protein tyrosine phosphorylation of two major proteins ( p120, p70 ) and ERK activation were markedly reduced, whereas ERK activation by epidermal growth factor was unaffected
Carmona-Cuenca et al., J Cell Physiol 2006 : EGF blocks NADPH oxidase activation by TGF-beta in fetal rat hepatocytes, impairing oxidative stress, and cell death
Flinder et al., J Cell Physiol 2011 : EGF induced ERK-activation downstream of FAK requires rac1-NADPH oxidase