◀ Back to CD79A
CD72 — CD79A
Pathways - manually collected, often from reviews:
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72/SHP1 complex (CD72-PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
SHP1 (PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72/SHP1 complex (CD72-PTPN6)
(modification, collaborate)
Adachi et al., J Biol Chem 2001
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
CD72 (CD72)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2/CD72 complex (BTK-PLCG2-CD72-SYK-CD79B-LYN-CD79A-BLNK)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
-
NCI Pathway Database BCR signaling pathway:
CD72 (CD72)
→
B-cell antigen/BCR complex/Btk/LYN/SYK/BLNK/PLCgamma2 complex (BTK-PLCG2-SYK-CD79B-LYN-CD79A-BLNK)
(modification, collaborate)
Fusaki et al., Eur J Immunol 2000
Text-mined interactions from Literome
Li et al., Arthritis Rheum 2008
(Autoimmune Diseases) :
Biochemical analyses indicated that in anergic B cells,
CD72 dominantly
down-regulated BCR signaling to limit the antigen induced elevation in [ Ca2+ ] i and the activation of NFATc1, NF-kappaB, MAPK, and Akt ... Mechanistically, CD72 was associated with, and regulated, the molecular adaptor Cbl-b in anergic B cells, suggesting that Cbl-b may play a role in mediating the negative
effects of
CD72 on
BCR signaling
Xu et al., J Immunol 2013
(Autoimmune Diseases...) :
We further demonstrated that Cd72(c) is a hypofunctional allele in
BCR signal inhibition and that
CD72 deficiency
induces severe autoimmune disease in the presence of Fas ( lpr )
Adachi et al., J Immunol 1998
:
Moreover, cross linking of
B cell Ag receptor (BCR) enhances both tyrosine phosphorylation of CD72 and association of
CD72 with SHP-1 in B cell line WEHI-231