Gene interactions and pathways from curated databases and text-mining

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MTOR — RPS6

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kimball et al., J Biol Chem 1999 : Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
Shao et al., Cancer Res 2004 (Cell Transformation, Neoplastic...) : p70 ribosomal protein S6 kinase activity was induced by K-Ras in a PI3K- and mTOR dependent manner
Tuhácková et al., Int J Mol Med 2004 : IL2 dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells ... IL2 dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells
Galbaugh et al., BMC cell biology 2006 : But lower levels of PI-3-K and mTOR inhibitors were required to block insulin induced phosphorylation of RPS6 than EGF induced phosphorylation, and insulin induced phosphorylation of elF4E and 4E-BP1 was not completely mTOR dependent suggesting some diversity of signaling for EGF and insulin
Mieulet et al., Am J Physiol Cell Physiol 2007 (Muscular Atrophy) : The phosphorylation of ribosomal protein S6 (rpS6) , eukaryotic initiation factor-4B (eIF4B), and eukaryotic elongation factor-2 ( eEF2 ) is predominantly regulated by mTOR in muscle cells
Knaup et al., Mol Cancer Res 2009 : However, certain proteins are believed to be preferentially translated during hypoxia via 5 ' terminal oligopyrimidine tract mechanisms with controversial discussion about the involvement of the mTOR dependent ribosomal protein S6 (rpS6)
Villanueva et al., Endocrinology 2009 : To determine the mechanisms by which leptin modulates mTORC1 in specific hypothalamic neurons, we immunohistochemically assessed the mTORC1 dependent phosphorylation of ribosomal protein S6 (pS6)
Li et al., J Immunol 2011 (HIV Infections...) : Targeted gene silencing of MyD88 ( short hairpin RNA ) and mTOR ( RNA interference ) inhibition resulted in TLR-4 mediated 70-kDa ribosomal protein S6 kinase activation and enhanced TNF-a release, whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages
Gundermann et al., J Appl Physiol 2012 (Hyperemia) : BFR exercise increased the phosphorylation of mTOR, S6 kinase 1, ribosomal protein S6 , ERK1/2, and Mnk1 interacting kinase 1 ( P < 0.05 ) with no changes in mTORC1 signaling in the SNP trial ( P > 0.05 )
Bonito-Oliva et al., Neuropharmacology 2013 : Haloperidol promotes mTORC1 dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1
Tamura et al., ISRN pharmacology 2013 : Rapamycin, an inhibitor of mTOR complex 1, reduced the level of HIF-1 a and blocked phosphorylation of ribosomal protein S6 kinase 1 (S6K) , a transcriptional regulator of mTOR , demonstrating that hypoxia activates mTOR/S6K/HIF-1 a signaling in CCA