◀ Back to SLC22A3

JAG1 — SLC22A3

Text-mined interactions from Literome

Zavadil et al., EMBO J 2004 : TGF-beta induced EMT was blocked by RNA silencing of HEY1 or JAG1 , and by chemical inactivation of Notch ... Our findings identify a new mechanism for functional integration of Jagged1/Notch signalling and coordinated activation of the Hey1 transcriptional repressor controlled by TGF-beta/Smad3, and demonstrate functional roles for Smad3, Hey1, and Jagged1/Notch in mediating TGF-beta induced EMT
Chen et al., Br J Cancer 2010 (Anoxia...) : Epithelial-to-mesenchymal transition is mediated, in part, by two transcription repressors, Snail and Slug, that are known to be targets of the Notch signaling pathway, and JAGGED1 induced Notch activation increases EMT
Wang et al., PloS one 2013 : To further address how these pathways coordinate in the process, we specifically disrupted Notch1 or Jagged1 in the endocardium of mouse embryonic hearts and showed that Jagged1-Notch1 signaling in the endocardium is essential for EMT and early valvular cushion formation