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ELN — TNF
Text-mined interactions from Literome
Starcher et al., Br J Dermatol 2000
(Cell Transformation, Neoplastic...) :
These studies suggest that
TNF-alpha plays no part in the accumulation of excessive
elastin in the skin during chronic UVB exposure
Kähäri et al., J Biol Chem 1992
:
The down-regulatory
effect of
TNF-alpha on
elastin promoter activity was abolished by co-transfections with a synthetic double stranded AP-1 oligomer ... These observations suggest that the inhibitory
effects of
TNF-alpha on
elastin gene expression involve the transcription factor AP-1
John et al., J Orthop Res 2010
:
In
response to
TNFalpha , tenocytes reduced their type I collagen deposition but increased their
elastin gene expression and highly upregulated their expression for MMP-1, pro-inflammatory ( TNFalpha, IL-1beta ) and immunoregulatory ( IL-6, IL-10 ) cytokines
Rédini et al., Biochem Biophys Res Commun 1988
:
Tumor Necrosis Factor-alpha (TNF-alpha) and Interferon-gamma (IFN-gamma) significantly
enhanced the
elastin degrading activity present in the culture media of both synoviocytes and chondrocytes
Kochevar et al., J Invest Dermatol 1994
:
These results suggest that excess
TNF-alpha ( or other mediator ) produced in C3H/HeN skin ( but not C3H/HeJ skin ) in response to UVB exposure is
involved in the mast cell increase and partial inhibition of
elastin increase, but that neither these mediators nor mast cell products are important mediators for the chronic UVB induced increases in neutrophils, glycosaminoglycans, and collagen