Zhao et al., Br J Ophthalmol 2007
(Diabetic Retinopathy) :
In retinal endothelial cells, TNFalpha stimulates the expression of VEGF-C , which in turn protects endothelial cells from apoptosis induced by TNFalpha or hyperglycaemia via VEGFR-2 and thus helps sustain retinal neovascularisation
Zhang et al., Arthritis Res Ther 2007
(Arthritis, Experimental...) :
TNF stimulated VEGF-C expression by OCPs and increased nuclear factor-kappa B (NF-kappaB) binding to an NF-kappaB sequence in the VEGF-C promoter ... In summary, TNF induces OCPs to produce VEGF-C through NF-kappaB, leading to significantly increased lymphangiogenesis in joints of arthritic mice
Ristimäki et al., J Biol Chem 1998
:
IL-1beta and tumor necrosis factor-alpha also stimulated the production of VEGF-C protein by the fibroblasts