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LEP — PDE3B

Text-mined interactions from Literome

Pyne et al., Diabetologia 2003 : In contrast, activation of beta-cell PDE3B could mediate the inhibitory effect of IGF-1 and leptin on insulin secretion
Sahu et al., J Neuroendocrinol 2013 : In the hypothalamus, leptin stimulates STAT3 activation, and induces PI3K and PDE3B activities, among others ... To address this possibility, the effect of wortmannin, a specific PI3K inhibitor, was examined on leptin induced PDE3B activity in the hypothalamus of male rats ... However, previous administration of wortmannin completely reversed the stimulatory effect of leptin on PDE3B activity in the hypothalamus
Zhao et al., J Clin Invest 1998 : In pancreatic beta cells, leptin causes the activation of PDE3B , which leads to marked inhibition of glucagon-like peptide-1 stimulated insulin secretion