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IGF2 — IGF2R
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Dip Interaction:
IGF2
—
IGF2R
(direct interaction, surface plasmon resonance)
Williams et al., Structure 2007*
-
IRef Dip Interaction:
IGF2
—
IGF2R
(direct interaction, nuclear magnetic resonance)
Williams et al., Structure 2007*
-
IRef Dip Interaction:
IGF2
—
IGF2R
(direct interaction, biochemical)
McKinnon et al., J Clin Endocrinol Metab 2001*
-
IRef Hprd Interaction:
IGF2
—
IGF2R
(in vivo)
Schmidt et al., J Biol Chem 1995*, O'Dell et al., Int J Biochem Cell Biol 1998*
-
IRef Hprd Interaction:
IGF2
—
IGF2R
(in vitro)
Schmidt et al., J Biol Chem 1995*, O'Dell et al., Int J Biochem Cell Biol 1998*
-
IRef Intact Interaction:
IGF2
—
IGF2R
(direct interaction, surface plasmon resonance)
Brown et al., EMBO J 2008*
-
IRef Intact Interaction:
IGF2
—
IGF2R
(direct interaction, x-ray crystallography)
Brown et al., EMBO J 2008*
-
IRef Ophid Interaction:
IGF2
—
IGF2R
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Rey et al., Int J Cancer 2000
(Breast Neoplasms...) :
The
mannose-6-phosphate/insulin-like growth factor 2 receptor ( Man-6-P/IGFII receptor ) is
involved in lysosomal enzyme sorting,
IGFII degradation and pro-TGFbeta activation
Sedlaczek et al., Br J Cancer 2003
(Hepatitis, Viral, Human...) :
IGF-2 signalling is mediated through IGF-1 receptor (IGF-1R), while mannose
6-phosphate/insulin-like growth factor-2 receptor ( M6P/IGF-2R )
controls pericellular levels of free
IGF-2
Damke et al., Biochem J 1992
:
IGF-I,
IGF-II and phorbol ester
increased the surface expression of the
M6P/IGF-II receptor and of MPR46
MacDonald et al., Endocrinology 1991
:
Furthermore, Man-6-P enhanced [ 125I
] IGF-II cross linking to the H-35 receptor by a constant ( approximately 80 % ) increment 1 ) when the cross linking reaction was conducted in buffers of different pH over the range 6.8-8.0, or 2 ) using cross linking agents differing in spacer arm length from 6.4-16.1 A. Washing membranes before assay with either Man-6-P ( pH 7.4 ) or 0.5 M NaCl ( pH 4.5 )
reduced the subsequent Man-6-P enhancement of [ 125I ]
IGF-II-receptor cross linking, suggesting that this phenomenon was actually due to displacement of inhibitory phosphomannosyl ligands bound endogenously to the Man-6-P sites of the receptor
Chu et al., Chin J Physiol 2009
(Heart Diseases) :
In this study, we hypothesized that
IGF-II may
induce cell apoptosis through
IGF2R but is dependent on IGF1R activity ... Taken together, these data provide new insight into the dual
role of
IGF-II in the control of IGF1R dependent cell apoptosis and involved activation of
IGF2R signaling
Matsumoto et al., In Vitro Cell Dev Biol Anim 2011
:
Recombinant
IGF2 induces IGF1R and
IGF2R expression in epithelial cells
Ku et al., Mol Nutr Food Res 2012
:
Furthermore, EGCG inhibited the IGF-I stimulated phosphorylation of the IGF-I receptor-beta ( IGF-IR ß ), the association of IGF-IR with the p66Shc protein, and the
IGF-II stimulated associations of the
IGF-II receptor with G ( ai-2 ) and p66Shc proteins, suggesting that EGCG selectively affects particular types of Shc and MAPK family members
Probst et al., Biochem J 2013
(Carcinoma, Squamous Cell...) :
The results of the present study demonstrate that
M6P/IGF2R does not
require a functional binding site for
insulin-like growth factor II for inhibition of anchorage independent growth and matrix invasion by SCC-VII cells
Weng et al., Food Chem Toxicol 2013
:
Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of
Leu27IGF-II induced
IGF-II receptor signaling
activation in cardiomyoblasts
Körner et al., Mol Cell Endocrinol 1996
:
IGF II increased the expression of
MPR 300 at the cell surface threefold that was completely abolished by wortmannin at 100-300 nM ... These results show that activation of PI3-kinase plays a critical role in the IGF II-stimulated redistribution of
MPR 300 initiated rather by
IGF II binding to tyrosine kinase receptors than to the MPR 300
Ellis et al., Mol Endocrinol 1996
(Breast Neoplasms...) :
Affinity for the insulin-like growth factor-II
(IGF-II) receptor inhibits autocrine
IGF-II activity in MCF-7 breast cancer cells
Zou et al., Cancer Res 1998
(Gastrointestinal Neoplasms) :
IGF-I and
IGF-II levels are
regulated by binding to the
IGF-II receptor , which is inactivated by mutation in human gastrointestinal ( GI ) tumors