Gene interactions and pathways from curated databases and text-mining

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IGF2 — IGF2R

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Rey et al., Int J Cancer 2000 (Breast Neoplasms...) : The mannose-6-phosphate/insulin-like growth factor 2 receptor ( Man-6-P/IGFII receptor ) is involved in lysosomal enzyme sorting, IGFII degradation and pro-TGFbeta activation
Sedlaczek et al., Br J Cancer 2003 (Hepatitis, Viral, Human...) : IGF-2 signalling is mediated through IGF-1 receptor (IGF-1R), while mannose 6-phosphate/insulin-like growth factor-2 receptor ( M6P/IGF-2R ) controls pericellular levels of free IGF-2
Damke et al., Biochem J 1992 : IGF-I, IGF-II and phorbol ester increased the surface expression of the M6P/IGF-II receptor and of MPR46
MacDonald et al., Endocrinology 1991 : Furthermore, Man-6-P enhanced [ 125I ] IGF-II cross linking to the H-35 receptor by a constant ( approximately 80 % ) increment 1 ) when the cross linking reaction was conducted in buffers of different pH over the range 6.8-8.0, or 2 ) using cross linking agents differing in spacer arm length from 6.4-16.1 A. Washing membranes before assay with either Man-6-P ( pH 7.4 ) or 0.5 M NaCl ( pH 4.5 ) reduced the subsequent Man-6-P enhancement of [ 125I ] IGF-II-receptor cross linking, suggesting that this phenomenon was actually due to displacement of inhibitory phosphomannosyl ligands bound endogenously to the Man-6-P sites of the receptor
Chu et al., Chin J Physiol 2009 (Heart Diseases) : In this study, we hypothesized that IGF-II may induce cell apoptosis through IGF2R but is dependent on IGF1R activity ... Taken together, these data provide new insight into the dual role of IGF-II in the control of IGF1R dependent cell apoptosis and involved activation of IGF2R signaling
Matsumoto et al., In Vitro Cell Dev Biol Anim 2011 : Recombinant IGF2 induces IGF1R and IGF2R expression in epithelial cells
Ku et al., Mol Nutr Food Res 2012 : Furthermore, EGCG inhibited the IGF-I stimulated phosphorylation of the IGF-I receptor-beta ( IGF-IR ß ), the association of IGF-IR with the p66Shc protein, and the IGF-II stimulated associations of the IGF-II receptor with G ( ai-2 ) and p66Shc proteins, suggesting that EGCG selectively affects particular types of Shc and MAPK family members
Probst et al., Biochem J 2013 (Carcinoma, Squamous Cell...) : The results of the present study demonstrate that M6P/IGF2R does not require a functional binding site for insulin-like growth factor II for inhibition of anchorage independent growth and matrix invasion by SCC-VII cells
Weng et al., Food Chem Toxicol 2013 : Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II induced IGF-II receptor signaling activation in cardiomyoblasts
Körner et al., Mol Cell Endocrinol 1996 : IGF II increased the expression of MPR 300 at the cell surface threefold that was completely abolished by wortmannin at 100-300 nM ... These results show that activation of PI3-kinase plays a critical role in the IGF II-stimulated redistribution of MPR 300 initiated rather by IGF II binding to tyrosine kinase receptors than to the MPR 300
Ellis et al., Mol Endocrinol 1996 (Breast Neoplasms...) : Affinity for the insulin-like growth factor-II (IGF-II) receptor inhibits autocrine IGF-II activity in MCF-7 breast cancer cells
Zou et al., Cancer Res 1998 (Gastrointestinal Neoplasms) : IGF-I and IGF-II levels are regulated by binding to the IGF-II receptor , which is inactivated by mutation in human gastrointestinal ( GI ) tumors