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CAPN11 — PTPN5
Text-mined interactions from Literome
Xu et al., J Neurosci 2009
:
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via
calpain mediated cleavage of
STEP
Mesfin et al., J Neurotrauma 2012
(Brain Injuries...) :
STEP ( 61 ) expression progressively increases after sublethal stretch with no change in
calpain mediated
STEP ( 33 ) formation, while lethal stretch injury results in STEP ( 33 ) formation via a NR2B containing NMDA receptor pathway within 1 h of injury ... In summary, these data demonstrate that previously characterized pathways of STEP regulation via the NMDA receptor are generally conserved in mechanical injury, and suggest that
calpain mediated cleavage of
STEP ( 33 ) should be further examined as an early marker of neuronal fate after stretch injury