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PIK3CA — SMAD3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Qiao et al., Cancer Lett 2006
(Neuroblastoma) :
GRP induced activation of
PI3-K , resulting in neuroblastoma cell growth promotion, is
potentiated by down-regulation of
TGF-beta/Smad signaling
Graham et al., Prostate 2009
(Neoplasm Metastasis...) :
PI3K/Akt dependent transcriptional regulation and activation of
BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells
Heger et al., J Cell Physiol 2010
(Cardiomegaly...) :
Specific inhibitors of
PI3K ( 10 microM LY290042 or 10 nM wortmannin ) or ERK ( 10 microM PD98059 ) also
blocked GDF15 induced hypertrophy and
SMAD activation