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IL33 — ST2

Text-mined interactions from Literome

Palmer et al., Cytokine 2008 : The IL-1 receptor accessory protein ( AcP ) is required for IL-33 signaling and soluble AcP enhances the ability of soluble ST2 to inhibit IL-33
Funakoshi-Tago et al., Cell Signal 2008 : IL-33 rapidly induced the formation of ST2L complex containing IL-1 receptor associated kinase (IRAK), however, lack of TRAF6 abolished the recruitment of IRAK to ST2L
Cayrol et al., Proc Natl Acad Sci U S A 2009 : We show that full-length IL-33 ( 1-270 ) binds and activates ST2 , similarly to IL-33 ( 112-270 ), and that cleavage by caspase-1 does not occur at the site initially proposed ( Ser ( 111 ) ), but rather after residue Asp ( 178 ) between the fourth and fifth predicted beta-strands of the IL-1-like domain
Mun et al., Cell Mol Life Sci 2010 (Bone Resorption) : This action was suppressed by anti-ST2 antibody, suggesting that IL-33 acts through its receptor ST2 , but not by the receptor activator of NF-?B ligand ( RANKL ) decoy, osteoprotegerin, or anti-RANKL antibody
Fursov et al., Hybridoma (Larchmt) 2011 (Hypersensitivity...) : ST2L activation by its ligand IL-33 has been implicated in Th2 mediated immunity, inflammation, and allergic responses in vivo
Schmieder et al., Cytokine 2012 (Neoplasm Metastasis...) : We also detected a counter-regulatory effect of IL-33 and IL-1 on the mRNA expression of soluble IL-33 receptor ST2 and membrane bound receptor ST2L
Hong et al., Immunol Res 2013 : IL-33 receptor complex is comprised of IL-1 receptor accessory protein ( IL-1RAcP ) and ST2 that are activated by IL-33 ligand binding